Editorial Central Corneal Thickness—Tonometry Artifact, or Something More?

reported that central corneal thickness (CCT) was an important predictive factor for the development of glaucoma among OHTS participants. 1 In a multivariate model that included intraocular pressure (IOP), CCT was the most powerful component of the predictive model. This finding was externally validated in the European Glaucoma Prevention Study, 2 and in the merged OHTS/European Glaucoma Prevention Study prediction model, each 40 �m of central corneal thinning confers a 2-fold increased risk of developing glaucoma over 5 years (hazard ratio [HR], 2.04; 95% confidence interval [CI], 1.70–2.45). 3 How does CCT influence glaucoma risk? Two possibilities are that CCT affects the accuracy of tonometry or perhaps CCT is linked at a more fundamental level to glaucoma pathophysiology. It has been known since th