RESEARCH ARTICLE ARTICALTICLE International Journal of Pharma and Bio Sciences BIOCHEMISTRY LIPID PROFILES IN SERUM SAMPLES OF SOME NIGERIAN MALE SUBJECTS

Excessive levels of cholesterol in blood circulation are strongly associated with progression of atherosclerosis. While the measurement of total cholesterol (TC) low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) are recommended in current cardiovascular screening algorithins, recent guidelines have emphasized the importance of non-high density lipoprotein cholesterol (non-HDL-C) as a predictor of cardiovascular risk, while others have strongly advocated the use of specific lipid ratios of TC to HDL cholesterol. This study examined clinical utility of atherogenic dyslipidemia, metabolic syndrome, non-HDL cholesterol and the lipid ratios (TC to HDL cholesterol, LDL to HDL cholesterol, TG to HDL cholesterol, non-HDL to HDL cholesterol) as an individual marker of cardiovascular events. Characterisation of the study subjects was given. The analyses of the biochemical parameters were done using Reflotron ® System. The TC, HDL and TG (total glyceride) were measured directly. LDL-C was estimated using the Friedewald formula: [TC] – [total HDL-C]-20 % of the TG = estimated LDL-C based on the fact that TC is the sum of HDL, LDL and VLDL. The VLDL was estimated as one-fifth of TG. This formula was used to estimate LDL-C and VLDL-C in the samples. For the purpose of therapeutic decisionmaking