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Metabonomic study of syndrome of liver qi stagnation and spleen deficiency in rats He�gu LUO,Jie DING, Guang�xin YUE, Jia�xu CHEN Depa rtment of Diagnostics o f T raditional Chinese Medicine,Beijing Universit y o f C hinese Medicine, Beijing 100029, China Objective: To determine the changes of the plasma metabolic phenotype in rats with chronic restraint stress (rats with syndrome of liver qi stagnation and spleen deficiency),so as to reveal the biological features of the syndrome of liver qi stagnation and spleen deficiency, and to examine potential application of metabonomic analysis in studies of syndromes in traditional Chinese medicine. Methods: Twenty�four male Sprague�Dawley rats were randomly divided into four groups:group A, 7 d nor