Review article UDC: 616-006.4:615-085:614.253:616-036 Archive of Oncology 2003;11(1):13-6.

Treatments based on theory and anecdote with extravagant public claims without being properly tested has become past time in medical practice. Only valid unbiased and relevant evidence obtained by methodology of clinical trials should be adopted in medical practice and practice guidelines. In such way clinical decisions are based on evidence rather than on authority. Inevitable part of clinical trials is medical ethics formally define