Nephrology Reviews 2010; volume 2:e6 Outcome of renal transplantation in Indian children with primary focal segmental glomerulosclerosis- a single center experience

Recurrence of focal segmental glomerulosclerosis (FSGS) following renal transplantation is associated with decreased allograft function and/or graft loss. The optimal specific management of recurrence during the posttransplant period is not yet clear. Plasmapheresis peri-operatively or following transplantation and other supportive measures such as higher doses of cyclosporine have been used in the clinical management of recurrence. We performed a retrospective analysis of ten children with FSGS who had renal transplants at our center between 1999 and 2008. Following transplantation, four (40%) patients developed recurrence of nephrotic syndrome (NS). We observed heterogeneity in the age at onset of NS, time to reach end-stage renal disease, and age at the time of transplant between those who had and did not have recurrences, but our small sample size precluded any definitive conclusions