OBSERVATIONS ON THE INHIBITION OF SULFONAMIDE ACTION BY PARA-AMINOBENZOIC ACID

Considerable interest has been aroused recently subjects following ingestion of para-aminobenzoic in the investigation of substances which inhibit acid with the activity of this drug when added in the action of the sulfonamide drugs. Lockwood vitro to normal urine (the bacteriostatic effect of (1) showed that peptones inhibit the action of sulfathiazole on the colon bacillus was utilized for sulfanilamide on streptococci. Stamp (2) iso- this purpose); (5) a study of the effect of oral lated certain fractions of streptococci, and Green administration of para-aminobenzoic acid on the (3) isolated fractions of brucella, which have bactericidal power of the blood of subjects re-similar activity with respect to the corresponding ceiving sulfonamides; and (6) the effect of para-organisms. West and Coburn (4) showed that aminobenzoic acid on rashes and fever due to under certain conditions coenzymes inhibit the sulfonamide toxicity. action of sulfapyridine on staphylococci. Mac-Leod (5) found that the action of sulfapyridine Quantitative relationship between the concentra-on the colon bacillus in a synthetic medium can be tion of sulfonamides and the inhibitory con-nullified by extracts of certain animal tissues. centration of para-aminobenzoic aci