Mesangial cell proliferation is common in glomerulonephritis but it is unclear if proliferation is associated with any in vivo alteration in phenotype. We investigated whether mesangial cells acquire smooth muscle-like characteristics in a rat model of mesangial proliferative nephritis induced with antibody to the Thy-i antigen present on mesangial cells. At day 3 glomeruli displayed de novo immunostaining for a-smooth muscle actin in a mesangial pattern, correlating with the onset of proliferation, and persisting until day 14. An increase in desmin and vimentin in mesangial regions was also noted. Immunoelectron microscopy confirmed that the actin-positive cells were mesangial cells, and double immunolabeling demonstrated that the smooth m...
Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isof...
Characterization of myosin heavy and light chains in cultured mesangial cells. Analysis by sodium do...
Recognised by their de novo expression of alpha-smooth muscle actin (SMA), recruitment of myofibrobl...
Enhanced expression of “muscle-specific” actin in glomerulonephritis. Increased expression of “muscl...
Differentiation of smooth muscle phenotypes in mouse mesangial cells. Smooth muscle α-actin (SMA) mR...
Regulation of smooth muscle α-actin expression and hypertrophy in cultured mesangial cells.Backgroun...
Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glo...
Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Extracellular matr...
The aim of the present study was to investigate the expression of alpha-smooth muscle actin (alpha-S...
Biochemical characterization of contractile proteins of rat cultured mesangial cells. We examined ch...
Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial prolifer...
To investigate the role of intracellular mitogen activated protein kinase (MAPKs, ERK, JNK and p38) ...
Changes in cell cycle protein expression during experimental mesangial proliferative glomerulonephri...
Mesangial cell abnormalities in spontaneously hypertensive rats before the onset of hypertension. To...
<p>Representative immunofluorescence micrographs show the glomerular expression of Hic-5, α-SMA, and...
Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isof...
Characterization of myosin heavy and light chains in cultured mesangial cells. Analysis by sodium do...
Recognised by their de novo expression of alpha-smooth muscle actin (SMA), recruitment of myofibrobl...
Enhanced expression of “muscle-specific” actin in glomerulonephritis. Increased expression of “muscl...
Differentiation of smooth muscle phenotypes in mouse mesangial cells. Smooth muscle α-actin (SMA) mR...
Regulation of smooth muscle α-actin expression and hypertrophy in cultured mesangial cells.Backgroun...
Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glo...
Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Extracellular matr...
The aim of the present study was to investigate the expression of alpha-smooth muscle actin (alpha-S...
Biochemical characterization of contractile proteins of rat cultured mesangial cells. We examined ch...
Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial prolifer...
To investigate the role of intracellular mitogen activated protein kinase (MAPKs, ERK, JNK and p38) ...
Changes in cell cycle protein expression during experimental mesangial proliferative glomerulonephri...
Mesangial cell abnormalities in spontaneously hypertensive rats before the onset of hypertension. To...
<p>Representative immunofluorescence micrographs show the glomerular expression of Hic-5, α-SMA, and...
Diversity and variability of smooth muscle phenotypes of renal arterioles as revealed by myosin isof...
Characterization of myosin heavy and light chains in cultured mesangial cells. Analysis by sodium do...
Recognised by their de novo expression of alpha-smooth muscle actin (SMA), recruitment of myofibrobl...