Protective role of methanolic extract of Polygonum glabrum willd against Cisplatin and Gentamycin induced nephrotoxicity in Albino rats

The nephroprotectic effect of Methanolic extract of Polygonum glabrum willd was studied in Cisplatin,Gentamycin induced Albino Rats. Oral administration of extract to albino rats [200mg/kg and 400mg/kg for 14, 8 days] produced significant (p<0.01) in animals treated with extract dependent manner, when compared to control drugs(cis platin 12mg/kg andgentamycin 80mg/kg). Treatment with extract 200mg/kg and 400mg/kg showed significant (P<0.01) improvement in body weight and serum and urine urea,uric acid,total protein,creatinine, when compared to nephroprotective control. Histopathological studies also confirmed biochemical findings. Thus our study shows that Methanolic extract of polygonum glabrum willd (200mg/kg and 400mg/kg) significantly improves the nephroprotectic activit