Hospital clusters of invasive Group B Streptococcal disease: a systematic review

Collin, SM
Lamb, P
Jauneikaite, E
Le Doare, K
Creti, R
Berardi, A
Heath, PT
Sriskandan, S
Lamagni, T

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Publication date

November 2019

DOI

10.1016/j.jinf.2019.11.008

Publisher

Elsevier BV

Journal

Journal of Infection

Language

English

Abstract

Objectives: To characterize outbreaks of invasive Group B Streptococcal (iGBS) disease in hospitals. Methods: Systematic review using electronic databases to identify studies describing iGBS outbreaks/clusters or cross-infection/acquisition in healthcare settings where ‘cluster’ was defined as ≥2 linked cases. PROSPERO CRD42018096297. Results: Twenty-five references were included describing 30 hospital clusters (26 neonatal, 4 adult) in 11 countries from 1966 to 2019. Cross-infection between unrelated neonates was reported in 19 clusters involving an early-onset (<7 days of life; n = 3), late-onset (7–90 days; n = 13) index case or colonized infant (n = 3) followed by one or more late-onset cases (median serial interval 9 days (IQR 3–17, ra...