Marine-derived compounds have been explored and considered as possible antitumor agents. In this study, we analyzed extracts of the sponge Cribrochalina vasculum for their ability to inhibit tumor cell proliferation. Screening identified two acetylenic compounds of similar structure that showed strong tumor-specific toxicity in non-small cell lung carcinoma (NSCLC) cells and small-cell lung carcinoma cells, and less prominent toxicity in ovarian carcinoma, while having no effect on normal cells. These acetylenic compounds were found to cause a time-dependent increase in activation of apoptotic signaling involving cleavage of caspase-9, caspase-3, and PARP, as well as apoptotic cell morphology in NSCLC cells, but not in normal fibroblasts. F...
Bioactive compounds extracted from marine organisms showed several biological activities. The presen...
Apoptosis, a form of programmed cell death, is a critical defence mechanism against the formation an...
Abstract Cancer is a leading cause of death in industrialized countries. Although mortality rates...
Marine-derived compounds have been explored and considered as possible antitumor agents. In this stu...
Triple negative breast cancer (TNBC) is currently the only group of breast cancers without an effect...
Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Ove...
Previous studies have shown that the cholinergic system plays a pivotal rule in small cell lung canc...
Despite the huge investment into research and the significant effort and advances made in the search...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Marine cyanobacteria have been proved to be an important source of potential anticancer drugs. Altho...
529-535The marine environment, a rich source of biological and chemical diversity, offers tremendous...
A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′-enyl)...
International audienceThe marine environment constitutes an extraordinary resource for the discovery...
Abstract: A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohe...
Naturally occurring 3-alkylpyridinium polymers (poly-APS) from the marine sponge Reniera sarai, cons...
Bioactive compounds extracted from marine organisms showed several biological activities. The presen...
Apoptosis, a form of programmed cell death, is a critical defence mechanism against the formation an...
Abstract Cancer is a leading cause of death in industrialized countries. Although mortality rates...
Marine-derived compounds have been explored and considered as possible antitumor agents. In this stu...
Triple negative breast cancer (TNBC) is currently the only group of breast cancers without an effect...
Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Ove...
Previous studies have shown that the cholinergic system plays a pivotal rule in small cell lung canc...
Despite the huge investment into research and the significant effort and advances made in the search...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
Marine cyanobacteria have been proved to be an important source of potential anticancer drugs. Altho...
529-535The marine environment, a rich source of biological and chemical diversity, offers tremendous...
A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′-enyl)...
International audienceThe marine environment constitutes an extraordinary resource for the discovery...
Abstract: A dibromotyrosine derivative, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohe...
Naturally occurring 3-alkylpyridinium polymers (poly-APS) from the marine sponge Reniera sarai, cons...
Bioactive compounds extracted from marine organisms showed several biological activities. The presen...
Apoptosis, a form of programmed cell death, is a critical defence mechanism against the formation an...
Abstract Cancer is a leading cause of death in industrialized countries. Although mortality rates...