The definitive cure for human immunodeficiency virus type-1 (HIV) infection is represented by the eradication of the virus from the patient's body. To reach this result, cells that are infected but do not produce the virus must become recognizable to be killed by the immune system. For this purpose, drugs defined "latency reverting agents" (LRA) that reactivate viral production are under investigation. A few clinical studies have been performed in HIV-infected patients treated with LRA and combined antiretroviral therapy (cART). The strategy is thus to combine cART and LRA to reactivate the virus and unmask latently infected cells that, because of cART, cannot produce a fully competent form of the virus. Unmasked cells can present viral ant...
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is the "shock ...
HIV infection is responsible for major morbidity, mortality, and cost to healthcare systems worldwid...
The “shock-and-kill” strategy is one of the most explored HIV-1 cure approaches to eliminate latent ...
The definitive cure for human immunodeficiency virus type-1 (HIV) infection is represented by the er...
When HIV infects host immune cells, it inserts its genetic material into their DNA enabling the viru...
Persistence of transcriptionally silent replication competent HIV-1 is a major barrier to clearance ...
Quiescent proviral genomes that persist during human immunodeficiency virus type 1 (HIV-1) infection...
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are th...
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are th...
Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, b...
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replic...
Antiretroviral therapy regimens durably suppress HIV replication, but do not cure infection. This is...
HIV cure is impeded by the persistence of a strenuous reservoir of latent but replication competent ...
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels in infected individuals ...
© 2018 Dr. Jonathan Colin JacobsonHIV-1 establishes a highly stable latent reservoir early in infect...
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is the "shock ...
HIV infection is responsible for major morbidity, mortality, and cost to healthcare systems worldwid...
The “shock-and-kill” strategy is one of the most explored HIV-1 cure approaches to eliminate latent ...
The definitive cure for human immunodeficiency virus type-1 (HIV) infection is represented by the er...
When HIV infects host immune cells, it inserts its genetic material into their DNA enabling the viru...
Persistence of transcriptionally silent replication competent HIV-1 is a major barrier to clearance ...
Quiescent proviral genomes that persist during human immunodeficiency virus type 1 (HIV-1) infection...
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are th...
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are th...
Antiretroviral therapy (ART) has dramatically improved the prognosis for people living with HIV-1, b...
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replic...
Antiretroviral therapy regimens durably suppress HIV replication, but do not cure infection. This is...
HIV cure is impeded by the persistence of a strenuous reservoir of latent but replication competent ...
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels in infected individuals ...
© 2018 Dr. Jonathan Colin JacobsonHIV-1 establishes a highly stable latent reservoir early in infect...
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is the "shock ...
HIV infection is responsible for major morbidity, mortality, and cost to healthcare systems worldwid...
The “shock-and-kill” strategy is one of the most explored HIV-1 cure approaches to eliminate latent ...