We report that TLR7, IL-6, and the adaptive immune system are essential for autoimmunity and glomerulonephritis but not for liver pathology in mice expressing the ubiquitin-binding-defective ABIN1[D485N] mutant. The blood and organs of ABIN1[D485N] mice have exceptionally high numbers of patrolling monocytes (pMo), which develop independently of IL-6 and the adaptive immune system. They are detectable in the blood months before autoimmunity and organ pathology are seen and may have diagnostic potential. The splenic pMo, inflammatory monocytes (iMo), and neutrophils of ABIN1[D485N] mice expressed high levels of mRNAs encoding proteins released during NETosis, which together with the high numbers of monocyte-derived dendritic cells (MoDCs) ma...
The three major autoimmune diseases (ADs) of the liver are primary biliary cholangitis (PBC), primar...
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, fem...
IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immun...
We report that TLR7, IL-6, and the adaptive immune system are essential for autoimmunity and glomeru...
Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus...
Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus...
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus er...
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear fac...
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus er...
© 2011 Dr. Evelyn TsantikosThis thesis dissects the nature of autoimmune disease development in mice...
Objective The BXSB.Yaa mouse strain is a model of systemic lupus erythematosus that is dependent on ...
Scurfy mice have a complete deficiency of functional regulatory T cells (Treg) due to a frameshift m...
Autoimmunity results from a breakdown in tolerance mechanisms that regulate autoreactive lymphocytes...
The three major autoimmune diseases (ADs) of the liver are primary biliary cholangitis (PBC), primar...
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, fem...
IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immun...
We report that TLR7, IL-6, and the adaptive immune system are essential for autoimmunity and glomeru...
Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus...
Polymorphisms in the TNIP1 gene encoding A20-binding inhibitor of NF-κB1 (ABIN1) predispose to lupus...
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus er...
The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear fac...
The genetic factors underlying the pathogenesis of lupus nephritis associated with systemic lupus er...
© 2011 Dr. Evelyn TsantikosThis thesis dissects the nature of autoimmune disease development in mice...
Objective The BXSB.Yaa mouse strain is a model of systemic lupus erythematosus that is dependent on ...
Scurfy mice have a complete deficiency of functional regulatory T cells (Treg) due to a frameshift m...
Autoimmunity results from a breakdown in tolerance mechanisms that regulate autoreactive lymphocytes...
The three major autoimmune diseases (ADs) of the liver are primary biliary cholangitis (PBC), primar...
Autoimmune hepatitis (AIH) is a chronic liver disease characterized by progressive inflammation, fem...
IL6 is a multifunctional cytokine that drives terminal B cell differentiation and secretion of immun...