Influence of digital hypothermia on lamellar events related to IL‐6/gp130 signalling in equine sepsis‐related laminitis

Interleukin-6 (IL-6) is consistently increased in the digital lamellae in different studies of sepsis-related laminitis (SRL). IL-6 signalling through the gp130 receptor activates similar signalling (i.e. mTORC1-related signalling) previously reported to be activated in models of endocrinopathic laminitis.To assess the activation state of signalling proteins downstream of IL-6/gp130 receptor complex activation in an experimental model of SRL.Randomised experimental study.Lamellar phospho-(P) protein concentrations downstream of the IL-6/gp130 receptors were assessed in the oligofructose (OF) model of SRL. Fifteen Standardbred horses were administered water (CON, n\ua0=\ua08) or oligofructose (OF, n\ua0=\ua07) via a nasogastric tube. At 12\ua0h post-OF/water administration, one randomly assigned forelimb was exposed to continuous digital hypothermia (CDH) by placement in ice water (ICE, maintained a