Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
- Hiley, C
- de Bruin, EC
- McGranahan, N
- Swanton, C
Publication date
January 2014
DOI Publisher
Springer Science and Business Media LLC Journal
issn:1474-760XAbstract
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design
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