Breast cancer risk following Hodgkin lymphoma radiotherapy in relation to menstrual and reproductive factors.

Cooke, R
Jones, ME
Cunningham, D
Falk, SJ
Gilson, D
Hancock, BW
Harris, SJ
Horwich, A
Hoskin, PJ
Illidge, T
Linch, DC
Lister, TA
Lucraft, HH
Radford, JA
Stevens, AM
Syndikus, I
Williams, MV
England and Wales Hodgkin Lymphoma Follow-up Group
Swerdlow, AJ

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Publication date

June 2013

DOI

10.1038/bjc.2013.219

Publisher

Springer Science and Business Media LLC

Journal

British Journal of Cancer

Abstract

Background Women treated with supradiaphragmatic radiotherapy (sRT) for Hodgkin lymphoma (HL) at young ages have a substantially increased breast cancer risk. Little is known about how menarcheal and reproductive factors modify this risk.Methods We examined the effects of menarcheal age, pregnancy, and menopausal age on breast cancer risk following sRT in case-control data from questionnaires completed by 2497 women from a cohort of 5002 treated with sRT for HL at ages <36 during 1956-2003.Results Two-hundred and sixty women had been diagnosed with breast cancer. Breast cancer risk was significantly increased in patients treated within 6 months of menarche (odds ratio (OR) 5.52, 95% confidence interval (CI) (1.97-15.46)), and increased sign...