Donated chemical probes for open science.
- Müller, S
- Ackloo, S
- Arrowsmith, CH
- Bauser, M
- Baryza, JL
- Blagg, J
- Böttcher, J
- Bountra, C
- Brown, PJ
- Bunnage, ME
- Carter, AJ
- Damerell, D
- Dötsch, V
- Drewry, DH
- Edwards, AM
- Edwards, J
- Elkins, JM
- Fischer, C
- Frye, SV
- Gollner, A
- Grimshaw, CE
- IJzerman, A
- Hanke, T
- Hartung, IV
- Hitchcock, S
- Howe, T
- Hughes, TV
- Laufer, S
- Li, VM
- Liras, S
- Marsden, BD
- Matsui, H
- Mathias, J
- O'Hagan, RC
- Owen, DR
- Pande, V
- Rauh, D
- Rosenberg, SH
- Roth, BL
- Schneider, NS
- Scholten, C
- Singh Saikatendu, K
- Simeonov, A
- Takizawa, M
- Tse, C
- Thompson, PR
- Treiber, DK
- Viana, AY
- Wells, CI
- Willson, TM
- Zuercher, WJ
- Knapp, S
- Mueller-Fahrnow, A
DOIAbstract
Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovati...
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