Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
- Kilpeläinen, Tuomas O.
- Bentley, Amy R.
- Noordam, Raymond
- Sung, Yun Ju
- Schwander, Karen
- Winkler, Thomas W.
- Jakupović, Hermina
- Chasman, Daniel I.
- Manning, Alisa
- Ntalla, Ioanna
- Aschard, Hugues
- Brown, Michael R.
- de las Fuentes, Lisa
- Franceschini, Nora
- Guo, Xiuqing
- Vojinovic, Dina
- Aslibekyan, Stella
- Feitosa, Mary F.
- Kho, Minjung
- Musani, Solomon K.
- Richard, Melissa
- Wang, Heming
- Wang, Zhe
- Bartz, Traci M.
- Bielak, Lawrence F.
- Campbell, Archie
- Dorajoo, Rajkumar
- Fisher, Virginia
- Hartwig, Fernando P.
- Horimoto, Andrea R. V. R.
- Li, Changwei
- Lohman, Kurt K.
- Marten, Jonathan
- Sim, Xueling
- Smith, Albert V.
- Tajuddin, Salman M.
- Alver, Maris
- Amini, Marzyeh
- Boissel, Mathilde
- Chai, Jin Fang
- Chen, Xu
- Divers, Jasmin
- Evangelou, Evangelos
- Gao, Chuan
- Graff, Mariaelisa
- Harris, Sarah E.
- He, Meian
- Hsu, Fang-Chi
- Jackson, Anne U.
- Zhao, Jing Hua
- Kraja, Aldi T.
- Kühnel, Brigitte
- Laguzzi, Federica
- Lyytikäinen, Leo-Pekka
- Nolte, Ilja M.
- Rauramaa, Rainer
- Riaz, Muhammad
- Robino, Antonietta
- Rueedi, Rico
- Stringham, Heather M.
- Takeuchi, Fumihiko
- van der Most, Peter J.
- Varga, Tibor V.
- Verweij, Niek
- Ware, Erin B.
- Wen, Wanqing
- Li, Xiaoyin
- Yanek, Lisa R.
- Amin, Najaf
- Arnett, Donna K.
- Boerwinkle, Eric
- Brumat, Marco
- Cade, Brian
- Canouil, Mickaël
- Chen, Yii-Der Ida
- Concas, Maria Pina
- Connell, John
- de Mutsert, Renée
- de Silva, H. Janaka
- de Vries, Paul S.
- Demirkan, Ayşe
- Ding, Jingzhong
- Eaton, Charles B.
- Faul, Jessica D.
- Friedlander, Yechiel
- Gabriel, Kelley P.
- Ghanbari, Mohsen
- Giulianini, Franco
- Gu, Chi Charles
- Gu, Dongfeng
- Harris, Tamara B.
- He, Jiang
- Heikkinen, Sami
- Heng, Chew-Kiat
- Hunt, Steven C.
- Ikram, M. Arfan
- Jonas, Jost B.
- Koh, Woon-Puay
- Komulainen, Pirjo
- Krieger, Jose E.
- Kritchevsky, Stephen B.
- Kutalik, Zoltán
- Kuusisto, Johanna
- Langefeld, Carl D.
- Langenberg, Claudia
- Launer, Lenore J.
- Leander, Karin
- Lemaitre, Rozenn N.
- Lewis, Cora E.
- Liang, Jingjing
- Liu, Jianjun
- Mägi, Reedik
- Manichaikul, Ani
- Meitinger, Thomas
- Metspalu, Andres
- Milaneschi, Yuri
- Mohlke, Karen L.
- Mosley, Thomas H.
- Murray, Alison D.
- Nalls, Mike A.
- Nang, Ei-Ei Khaing
- Nelson, Christopher P.
- Nona, Sotoodehnia
- Norris, Jill M.
- Nwuba, Chiamaka Vivian
- O’Connell, Jeff
- Palmer, Nicholette D.
- Papanicolau, George J.
- Pazoki, Raha
- Pedersen, Nancy L.
- Peters, Annette
- Peyser, Patricia A.
- Polasek, Ozren
- Porteous, David J.
- Poveda, Alaitz
- Raitakari, Olli T.
- Rich, Stephen S.
- Risch, Neil
- Robinson, Jennifer G.
- Rose, Lynda M.
- Rudan, Igor
- Schreiner, Pamela J.
- Scott, Robert A.
- Sidney, Stephen S.
- Sims, Mario
- Smith, Jennifer A.
- Snieder, Harold
- Sofer, Tamar
- Starr, John M.
- Sternfeld, Barbara
- Strauch, Konstantin
- Tang, Hua
- Taylor, Kent D.
- Tsai, Michael Y.
- Tuomilehto, Jaakko
- Uitterlinden, André G.
- van der Ende, M. Yldau
- van Heemst, Diana
- Voortman, Trudy
- Waldenberger, Melanie
- Wennberg, Patrik
- Wilson, Gregory
- Xiang, Yong-Bing
- Yao, Jie
- Yu, Caizheng
- Yuan, Jian-Min
- Zhao, Wei
- Zonderman, Alan B.
- Becker, Diane M.
- Boehnke, Michael
- Bowden, Donald W.
- de Faire, Ulf
- Deary, Ian J.
- Elliott, Paul
- Esko, Tõnu
- Freedman, Barry I.
- Froguel, Philippe
- Gasparini, Paolo
- Gieger, Christian
- Kato, Norihiro
- Laakso, Markku
- Lakka, Timo A.
- Lehtimäki, Terho
- Magnusson, Patrik K. E.
- Oldehinkel, Albertine J.
- Penninx, Brenda W. J. H.
- Samani, Nilesh J.
- Shu, Xiao-Ou
- van der Harst, Pim
- Van Vliet-Ostaptchouk, Jana V.
- Vollenweider, Peter
- Wagenknecht, Lynne E.
- Wang, Ya X.
- Wareham, Nicholas J.
- Weir, David R.
- Wu, Tangchun
- Zheng, Wei
- Zhu, Xiaofeng
- Evans, Michele K.
- Franks, Paul W.
- Gudnason, Vilmundur
- Hayward, Caroline
- Horta, Bernardo L.
- Kelly, Tanika N.
- Liu, Yongmei
- North, Kari E.
- Pereira, Alexandre C.
- Ridker, Paul M.
- Tai, E. Shyong
- van Dam, Rob M.
- Fox, Ervin R.
- Kardia, Sharon L. R.
- Liu, Ching-Ti
- Mook-Kanamori, Dennis O.
- Province, Michael A.
- Redline, Susan
- van Duijn, Cornelia M.
- Rotter, Jerome I.
- Kooperberg, Charles B.
- Gauderman, W. James
- Psaty, Bruce M.
- Rice, Kenneth
- Munroe, Patricia B.
- Fornage, Myriam
- Cupples, L. Adrienne
- Rotimi, Charles N.
- Morrison, Alanna C.
- Rao, Dabeeru C.
- Loos, Ruth J. F.
Publication date
January 2019
DOI Publisher
Springer Science and Business Media LLC Language
EnglishAbstract
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX...
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