Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is used as a nasal decongestant. Studies on lerimazoline are rare, and its pharmacological profile is not completely understood. Here, we analyzed the affinity of lerimazoline for dopamine receptor D2, serotonin 5-HT1A and 5-HT2A receptors and alpha(1)-adrenoceptor, and investigated lerimazoline contractile effects in isolated rat thoracic aorta. We also determined the effect of several antagonists on the contractile response to lerimazoline, including prazosin (alpha(1)-adrenoceptor antagonist), RX 821002 and rauwolscine (alpha(2)-adrenoceptor antagonists), JP 1302 (alpha(2C)-adrenoceptor antagonist), methiothepin (non-selective 5-HT receptor ant...
Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelation...
1 Contractile responses produced by the alpha 1-adrenoceptor selective agonist, phenylephrine, and t...
1 the role of alpha (2)-adrenoceptors in the response of aorta smooth muscle rings to the alpha (2)-...
Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is us...
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decong...
1. Ten racemic β-alkoxy-β-phenylethylamines were found to elicit concentration dependent contraction...
Trace amines including β-phenylethylamine (β-PEA) and amphetamines classically exert pharmacological...
1. Ten racemic ~-alkoxy-~-phenylethylamines were found to elicit concentrationdependent contraction...
Mouse thoracic aorta contracts to 5-hydroxytryptamine through mainly 5-HT2A receptors (McKune & ...
We studied the effects of 5-HT in resistance vessels. Compounds acting on 5-HT2A and 5-HT1B receptor...
Trace amines including tyramine and β-phenylethylamine (β-PEA) increase blood pressure and cause vas...
High concentrations of histamine (greater than 10 microM) contract rat aortic rings and the effect i...
WOS: 000378646700040PubMed ID: 27513427Background/aim: This study investigates whether 1-(2-trifluor...
WOS: 000336557600001PubMed ID: 24704610We previously showed that endothelin A (ETA) receptor antagon...
Endothelium-dependent contractions to acetylcholine and endothelium-independent contractions to oxyg...
Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelation...
1 Contractile responses produced by the alpha 1-adrenoceptor selective agonist, phenylephrine, and t...
1 the role of alpha (2)-adrenoceptors in the response of aorta smooth muscle rings to the alpha (2)-...
Lerimazoline is a sympathomimetic drug that belongs to the imidazoline class of compounds, and is us...
Vasoconstrictive properties of sympathomimetic drugs are the basis of their widespread use as decong...
1. Ten racemic β-alkoxy-β-phenylethylamines were found to elicit concentration dependent contraction...
Trace amines including β-phenylethylamine (β-PEA) and amphetamines classically exert pharmacological...
1. Ten racemic ~-alkoxy-~-phenylethylamines were found to elicit concentrationdependent contraction...
Mouse thoracic aorta contracts to 5-hydroxytryptamine through mainly 5-HT2A receptors (McKune & ...
We studied the effects of 5-HT in resistance vessels. Compounds acting on 5-HT2A and 5-HT1B receptor...
Trace amines including tyramine and β-phenylethylamine (β-PEA) increase blood pressure and cause vas...
High concentrations of histamine (greater than 10 microM) contract rat aortic rings and the effect i...
WOS: 000378646700040PubMed ID: 27513427Background/aim: This study investigates whether 1-(2-trifluor...
WOS: 000336557600001PubMed ID: 24704610We previously showed that endothelin A (ETA) receptor antagon...
Endothelium-dependent contractions to acetylcholine and endothelium-independent contractions to oxyg...
Vascular smooth muscle contraction involves multiple signal-transduction pathways, the interrelation...
1 Contractile responses produced by the alpha 1-adrenoceptor selective agonist, phenylephrine, and t...
1 the role of alpha (2)-adrenoceptors in the response of aorta smooth muscle rings to the alpha (2)-...