Karakteristike farmaceutskih oblika lekova za decu - aspekti individualizacije terapije

Pediatric oral drug dosage forms can be scientifically challenging to develop, and the choice of which formulation type to develop is often dictated by the physicochemical properties and the taste of the active drug substance, along with the intended dose. The physicochemical and organoleptic properties of the active drug substance such as solubility, chemical stability, and taste along with the intended dose can determine which formulations are feasible to develop. Oral pediatric formulation are available in different varieties and can be either a ready-to-use formulation such as asolution, syrup, suspension, tablet, or can also be a formulation that requires manipulation such as a powder for constitution to a suspension, tablet for constitution to a suspension, powder for constitution to a solution, drops for reconstitution to a suspension et al. Increasing knowledge into personalized medicine has demonstrated the need for individual dosing and pharmaceutical dosage forms enabling a flexible.Oralni farmaceutski oblici za decu predstavljaju izazov za formulaciju, a sam izbor vrste oblika zavisi od fizičko-hemijskih i organoleptičkih osobina lekovite supstance, kao i od predviđene doze. Oralni farmaceutski oblici za pedijatrijske pacijente mogu biti dostupni u vidu formulacija spremnih za upotrebu - rastvori, sirupi, suspenzije, tablete i drugi, ili u vidu formulacija koje zahtevaju dodatnu pripremu pre primene - prašak za izradu suspenzije, tablete za izradu suspenzije, prašak za izradu rastvora, kapi za izradu rastvora i drugi. Takođe se, u nedostatku pogodnog komercijalnog oblika leka za primenu kod dece različitog uzrasta, izrađuju magistralni preparati da bi se omogućilo precizno doziranje. U svetlu 'personalizovane medicine' smatra se da su individualizovana terapija i fleksibilni farmaceutski oblici budućnost