An accurate coulometric method for the chlorometric determination of sulfonamides

A coulometric method for the chlorometric determination of microquantities (0.04-0.1 mg) of sulphaphenazole, sulphadimidine and sulphamerazine, is described. The titration is carried out with a constant current of 2 mA, in the presence of methyl orange as indicator. The results obtained are accurate and reproducible; the method is simple and rapid and can be applied to routine analysis of investigated sulfonamides, within the concentrations examined