International audienceBackground information. Rho GTPases are important regulators of cytoskeleton dynamics and cell adhesion. RhoU/ Wrch-1 is a Rho GTPase which shares sequence similarities with Rac1 and Cdc42 (cell division cycle 42), but has also extended N-and C-terminal domains. The N-terminal extension promotes binding to SH3 (Src homology 3)-domain-containing adaptors, whereas the C-terminal extension mediates membrane targeting through palmitoyl-ation of its non-conventional CAAX box. RhoU/Wrch-1 possesses transforming activity, which is negatively regulated by its N-terminal extension and depends on palmitoylation. Results. In the present study, we have shown that RhoU is localized to podosomes in osteoclasts and c-Src-expressing c...
Cell migration is critical for normal development and for pathological processes including cancer ce...
Cell migration is critical to the development and maintenance of higher organisms, and is required f...
AbstractRho and rac, two members of the ras-related superfamily of small GTPases, regulate the polym...
AbstractBackground: The ability of a cell to polarize and move is governed by remodeling of the cell...
The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin cytos...
Integrin-mediated adhesion is a critical regulator of cell migration. Here we demonstrate that integ...
The GTP-binding proteins RhoA, Cdc42 and Rac1 regulate the organization and turnover of the cytoskel...
BACKGROUND: The ability of a cell to polarize and move is governed by remodeling of the cellular ...
Previously, we and others have shown that RhoA and ROCK signaling are required for negatively regula...
The Rho GTPases have mainly been studied in association with their roles in the regulation of actin...
The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell mig...
AbstractCadherin-dependent epithelial cell-cell adhesion is thought to be regulated by Rho family sm...
Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structu...
Cadherins are calcium-dependent cell-cell adhesion molecules that require the interaction of the cyt...
AbstractThe small GTPase Rho regulates several actomyosin-based cellular processes such as cell adhe...
Cell migration is critical for normal development and for pathological processes including cancer ce...
Cell migration is critical to the development and maintenance of higher organisms, and is required f...
AbstractRho and rac, two members of the ras-related superfamily of small GTPases, regulate the polym...
AbstractBackground: The ability of a cell to polarize and move is governed by remodeling of the cell...
The binding of extracellular matrix proteins to integrins triggers rearrangements in the actin cytos...
Integrin-mediated adhesion is a critical regulator of cell migration. Here we demonstrate that integ...
The GTP-binding proteins RhoA, Cdc42 and Rac1 regulate the organization and turnover of the cytoskel...
BACKGROUND: The ability of a cell to polarize and move is governed by remodeling of the cellular ...
Previously, we and others have shown that RhoA and ROCK signaling are required for negatively regula...
The Rho GTPases have mainly been studied in association with their roles in the regulation of actin...
The low molecular weight GTP-binding protein RhoA regulates many cellular events, including cell mig...
AbstractCadherin-dependent epithelial cell-cell adhesion is thought to be regulated by Rho family sm...
Cell migration is dependent on the dynamic formation and disassembly of actin filament-based structu...
Cadherins are calcium-dependent cell-cell adhesion molecules that require the interaction of the cyt...
AbstractThe small GTPase Rho regulates several actomyosin-based cellular processes such as cell adhe...
Cell migration is critical for normal development and for pathological processes including cancer ce...
Cell migration is critical to the development and maintenance of higher organisms, and is required f...
AbstractRho and rac, two members of the ras-related superfamily of small GTPases, regulate the polym...