International audienceRas interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mito-genic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase sig-naling by regulating the scaffolding activity of KSR
AbstractThe Raf/Mek/Erk signaling pathway, activated downstream of Ras primarily to promote prolifer...
AbstractKsr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role ...
Ras proteins have been implicated in up to 30% of all human cancers. However, in some tissues the i...
AbstractRas interacts with numerous downstream effectors to transmit a diverse array of cellular sig...
SummaryRAS proteins conduct signaling from surface receptors to cytoplasmic effectors, and RAS gain-...
AbstractKinase suppressor of ras (ksr) is required for efficient signal transmission within the RAS/...
The Ras-mitogen-activated protein (MAP) kinase pathway is a highly conserved eukaryotic signal trans...
M-Ras is a Ras-related protein that shares approximately 55% identity with K-Ras and TC21. The M-Ras...
Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiate...
The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras i...
Genetic screens for modifiers of activated Ras phenotypes have identified a novel protein, kinase su...
Rat sarcoma (RAS) family members are small GTPases that control a number of signaling pathways impor...
The small G protein, RAS, transduces signals from receptor tyrosine kinases at the plasma membrane t...
Ras proteins are small guanosine triphosphatases involved in the regulation of important cellular fu...
The discovery of a new downstream target for the Ras GTPases — a Nore1–Mst1 protein complex — reveal...
AbstractThe Raf/Mek/Erk signaling pathway, activated downstream of Ras primarily to promote prolifer...
AbstractKsr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role ...
Ras proteins have been implicated in up to 30% of all human cancers. However, in some tissues the i...
AbstractRas interacts with numerous downstream effectors to transmit a diverse array of cellular sig...
SummaryRAS proteins conduct signaling from surface receptors to cytoplasmic effectors, and RAS gain-...
AbstractKinase suppressor of ras (ksr) is required for efficient signal transmission within the RAS/...
The Ras-mitogen-activated protein (MAP) kinase pathway is a highly conserved eukaryotic signal trans...
M-Ras is a Ras-related protein that shares approximately 55% identity with K-Ras and TC21. The M-Ras...
Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiate...
The genetic alterations in cancer cells are tightly linked to signaling pathway dysregulation. Ras i...
Genetic screens for modifiers of activated Ras phenotypes have identified a novel protein, kinase su...
Rat sarcoma (RAS) family members are small GTPases that control a number of signaling pathways impor...
The small G protein, RAS, transduces signals from receptor tyrosine kinases at the plasma membrane t...
Ras proteins are small guanosine triphosphatases involved in the regulation of important cellular fu...
The discovery of a new downstream target for the Ras GTPases — a Nore1–Mst1 protein complex — reveal...
AbstractThe Raf/Mek/Erk signaling pathway, activated downstream of Ras primarily to promote prolifer...
AbstractKsr has been genetically defined as a component of the Ras/MAP kinase pathway, but its role ...
Ras proteins have been implicated in up to 30% of all human cancers. However, in some tissues the i...
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