Identification of seven loci affecting mean telomere length and their association with disease
- Codd, Veryan
- Nelson, Christopher P
- Albrecht, Eva
- Mangino, Massimo
- Deelen, Joris
- Buxton, Jessica L
- Hottenga, Jouke Jan
- Fischer, Krista
- Esko, Tõnu
- Surakka, Ida
- Broer, Linda
- Nyholt, Dale R
- Leach, Irene Mateo
- Salo, Perttu
- Hägg, Sara
- Matthews, Mary K
- Palmen, Jutta
- Norata, Giuseppe D
- O'Reilly, Paul F
- Saleheen, Danish
- Amin, Najaf
- Balmforth, Anthony J
- Beekman, Marian
- de Boer, Rudolf A
- Böhringer, Stefan
- Braund, Peter S
- Burton, Paul R
- Craen, Anton J Mde
- Denniff, Matthew
- Dong, Yanbin
- Douroudis, Konstantinos
- Dubinina, Elena
- Eriksson, Johan G
- Garlaschelli, Katia
- Guo, Dehuang
- Hartikainen, Anna-Liisa
- Henders, Anjali K
- Houwing-Duistermaat, Jeanine J
- Kananen, Laura
- Karssen, Lennart C
- Kettunen, Johannes
- Klopp, Norman
- Lagou, Vasiliki
- van Leeuwen, Elisabeth M
- Madden, Pamela A
- Mägi, Reedik
- Magnusson, Patrik K E
- Männistö, Satu
- McCarthy, Mark I
- Medland, Sarah E
- Mihailov, Evelin
- Montgomery, Grant W
- Oostra, Ben A
- Palotie, Aarno
- Peters, Annette
- Pollard, Helen
- Pouta, Anneli
- Prokopenko, Inga
- Ripatti, Samuli
- Salomaa, Veikko
- Suchiman, H Eka D
- Valdes, Ana M
- Verweij, Niek
- Viñuela, Ana
- Wang, Xiaoling
- Wichmann, H-Erich
- Widen, Elisabeth
- Willemsen, Gonneke
- Wright, Margaret J
- Xia, Kai
- Xiao, Xiangjun
- van Veldhuisen, Dirk J
- Catapano, Alberico L
- Tobin, Martin D
- Hall, Alistair S
- Blakemore, Alexandra I F
- van Gilst, Wiek H
- Zhu, Haidong
- consortium, CARDIoGRAM
- Erdmann, Jeanette
- Reilly, Muredach P
- Kathiresan, Sekar
- Schunkert, Heribert
- Talmud, Philippa J
- Pedersen, Nancy L
- Perola, Markus
- Ouwehand, Willem
- Kaprio, Jaakko
- Martin, Nicholas G
- van Duijn, Cornelia M
- Hovatta, Iiris
- Gieger, Christian
- Metspalu, Andres
- Boomsma, Dorret I
- Jarvelin, Marjo-Riitta
- Slagboom, P Eline
- Thompson, John R
- Spector, Tim D
- van der Harst, Pim
- Samani, Nilesh J
DOIAbstract
Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer and several age-associated diseases. We report here a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals. We identified seven loci, including five new loci, associated with mean LTL (P < 5 × 10(-8)). Five of the loci contain candidate genes (TERC, TERT, NAF1, OBFC1 and RTEL1) that are known to be involved in telomere biology. Lead SNPs at two loci (TERC and TERT) associate with several cancers and other diseases, including idiopathic pulmonary fibrosis. Moreover, a genetic risk score analysis combining lead variants at all 7 loci in 22,233 coronary artery disease cases and 64,762 ...
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