This dissertation consists of two parts. The first part contains a discussion of the 'fine-tuning' and 'naturalness ' problems in grand unified theories. It is argued that, while it is impossible to solve these problems in conventional theories which contain scalars, supersymmetric theories that require no fine tuning can be constructed. In these theories the problem reduces to that of obtaining a light Higgs doublet at the tree level, without any unnatural adjustment of parameters. A realistic supersymmetric grand unified theory that has this feature is constructed. It is based on the gauge group SO(10). Supersymmetry is explicitly broken through terms of dimension two. The second part is an analysis of the interaction of fermions with ...