Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects, methods for determining amino acid sequences of serum antibody CDR3 and abundancy levels are described. In some aspects, methods for determining nucleic acid sequences of antibody variable region sequences and the frequency thereof in biological samples are provided. Furthermore, the invention provides methods for identification and generation of antibodies or antigen-binding fragments that comprise highly-represented CDR domains.Board of Regents, University of Texas Syste
Mass spectrometric approaches have recently gained increasing access to molecular immunology and sev...
Summary table containing all reported antibodies extracted from the different studies (indicated in ...
In many diseases (e.g. autoimmune diseases, cancer), a humoral immune response is thought to be invo...
Methods and compositions for identification of candidate antigen-specific variable regions as well a...
Methods and compositions for identification of candidate antigen-specific variable regions as well a...
ABSTRACT: Characterizing the in vivo dynamics of the polyclonal antibody repertoire in serum, such a...
There are many ways in which the use of antibodies and antibody selection can be improved and develo...
Following the completion of the human genome sequence, post-genomic efforts have shifted the focus t...
This thesis, which is based on four original papers, covers different aspects of antibody developmen...
The development of in vitro antibody selection technologies has allowed overcoming some limitations ...
The vast repertoire of immunoglobulins produced by the immune system is a consequence of the huge am...
In cancer and autoimmune diseases, immunoglobulins with a specific molecular signature that could po...
Today’s proteomic analyses are generating increasing numbers of biomarkers, making it essential to p...
The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the ...
Gene as the basic functional unit of DNA encodes information about the product such as protein. The ...
Mass spectrometric approaches have recently gained increasing access to molecular immunology and sev...
Summary table containing all reported antibodies extracted from the different studies (indicated in ...
In many diseases (e.g. autoimmune diseases, cancer), a humoral immune response is thought to be invo...
Methods and compositions for identification of candidate antigen-specific variable regions as well a...
Methods and compositions for identification of candidate antigen-specific variable regions as well a...
ABSTRACT: Characterizing the in vivo dynamics of the polyclonal antibody repertoire in serum, such a...
There are many ways in which the use of antibodies and antibody selection can be improved and develo...
Following the completion of the human genome sequence, post-genomic efforts have shifted the focus t...
This thesis, which is based on four original papers, covers different aspects of antibody developmen...
The development of in vitro antibody selection technologies has allowed overcoming some limitations ...
The vast repertoire of immunoglobulins produced by the immune system is a consequence of the huge am...
In cancer and autoimmune diseases, immunoglobulins with a specific molecular signature that could po...
Today’s proteomic analyses are generating increasing numbers of biomarkers, making it essential to p...
The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the ...
Gene as the basic functional unit of DNA encodes information about the product such as protein. The ...
Mass spectrometric approaches have recently gained increasing access to molecular immunology and sev...
Summary table containing all reported antibodies extracted from the different studies (indicated in ...
In many diseases (e.g. autoimmune diseases, cancer), a humoral immune response is thought to be invo...