Eﬀects of a Subchronic Intoxication with Cadmium in the Hippocampus of Rats Fed a Soybean-Based Diet

Plateo Pignatari, Maria Gabriela
Della Vedova, Maria Cecilia
Perez Diaz MF
Navigatore Fonzo, Lorena Silvina
Sanchez, S.E.
Gimenez, Maria Sofia
Ramirez, Dario

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Publication date

December 2018

Publisher

Applied Cell Biology

Journal

2320-1991

Abstract

Experimental and population studies have shown that sub chronic exposure tocadmium (Cd) causes severe toxic eﬀects in several organs including in the brain,but information on the eﬀects in the hippocampus (Hp) is rare. Soybean is animportant source of protein and isoﬂavones. Herein we hypothesized that a subchronic cadmium-intoxication throughout the drinking water can cause oxidative/inﬂammation changes and apoptosis in the Hp; and that a soybean-based diet(SBD) can modulate these eﬀects. To accomplish this goal, we fed 4 groups offemale Wistar-rats for 60 days as follows: casein-based diet + tap water (CBD);CBD + tap water with 15 ppm Cd (CBD + Cd); soybean-based diet + tap water(SBD); and SBD + tap water with 15 ppm Cd (SBD + Cd). After ...

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Eﬀects of a Subchronic Intoxication with Cadmium in the Hippocampus of Rats Fed a Soybean-Based Diet

Abstract

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Eﬀects of a Subchronic Intoxication with Cadmium in the Hippocampus of Rats Fed a Soybean-Based Diet

Abstract

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