Objectives: To establish the frequency of JAK2, MPL and CALR mutations in Argentinean patients with BCR-ABL1-negative myeloproliferative neoplasms (MPN) and to compare their clinical and haematological features. Methods: Mutations of JAK2V617F, JAK2 exon 12, MPL W515L/K and CALR were analysed in 439 Argentinean patients with BCR-ABL1-negative MPN, including 176 polycythemia vera (PV), 214 essential thrombocythemia (ET) and 49 primary myelofibrosis (PMF). Results: In 94.9% of PV, 85.5% ET and 85.2% PMF, we found mutations in JAK2, MPL or CALR. 74.9% carried JAK2V617F, 12.3% CALR mutations, 2.1% MPL mutations and 10.7% were triple negative. In ET, nine types of CALR mutations were identified, four of which were novel. PMF patients were limite...
[No abstract available]373211214Baxter, E.J., Scott, L.M., Campbell, P.J., East, C., Fourouclas, N.,...
Objective: Calreticulin (CALR) plays important roles in cell proliferation, apoptosis, and immune re...
Dissertation (MSc)--University of Pretoria, 2016.The myeloproliferative neoplasms (MPN), formerly re...
Objectives: To establish the frequency of JAK2, MPL and CALR mutations in Argentinean patients with...
Introduction: Over the past decade, we have moved on from a predominantly morphological and clinical...
Introduction: This study aimed to verify the association between the JAK2 46/1 haplotype (V617F posi...
BACKGROUND: Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent ...
Objective: To detect the calreticulin gene mutation in myeloproliferative neoplasms and its clinicoh...
Introduction: BCR-ABL1-negative myeloproliferative disorders are a sub-group of myeloproliferative n...
Context and objectiveBy using molecular markers, it is possible to gain information on both the clas...
BACKGROUND: Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent ...
Mutations of JAK2V617F, CALR, and MPL genes confirm the diagnosis of myeloproliferative neoplasm (MP...
Objective: Detection of MPL and JAK2 exon12 gene mutation in myeloproliferative neoplasms (MPN) in J...
Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative mye...
International audienceMyeloproliferative neoplasms are clonal hematopoietic stem cell disorders char...
[No abstract available]373211214Baxter, E.J., Scott, L.M., Campbell, P.J., East, C., Fourouclas, N.,...
Objective: Calreticulin (CALR) plays important roles in cell proliferation, apoptosis, and immune re...
Dissertation (MSc)--University of Pretoria, 2016.The myeloproliferative neoplasms (MPN), formerly re...
Objectives: To establish the frequency of JAK2, MPL and CALR mutations in Argentinean patients with...
Introduction: Over the past decade, we have moved on from a predominantly morphological and clinical...
Introduction: This study aimed to verify the association between the JAK2 46/1 haplotype (V617F posi...
BACKGROUND: Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent ...
Objective: To detect the calreticulin gene mutation in myeloproliferative neoplasms and its clinicoh...
Introduction: BCR-ABL1-negative myeloproliferative disorders are a sub-group of myeloproliferative n...
Context and objectiveBy using molecular markers, it is possible to gain information on both the clas...
BACKGROUND: Philadelphia negative myeloproliferative neoplasms (MPNs) are characterized by frequent ...
Mutations of JAK2V617F, CALR, and MPL genes confirm the diagnosis of myeloproliferative neoplasm (MP...
Objective: Detection of MPL and JAK2 exon12 gene mutation in myeloproliferative neoplasms (MPN) in J...
Mutations in JAK2, MPL and CALR are highly relevant to the Philadelphia chromosome (Ph)-negative mye...
International audienceMyeloproliferative neoplasms are clonal hematopoietic stem cell disorders char...
[No abstract available]373211214Baxter, E.J., Scott, L.M., Campbell, P.J., East, C., Fourouclas, N.,...
Objective: Calreticulin (CALR) plays important roles in cell proliferation, apoptosis, and immune re...
Dissertation (MSc)--University of Pretoria, 2016.The myeloproliferative neoplasms (MPN), formerly re...