[eng] Dopaminergic neurons (DAn) were efficiently differentiated from 6 different iPSC lines derived from a 2 control, 3 PD lines, and an isogenic PD line. We characterize the culture at different time point in order to verify the composition of the culture. At day 35 almost 50% of the cells expressed the neuronal marker TUJ1, of which 20% were of DA lineage as judged by TH expression. No astrocytes were found in the culture. Interestingly at day 50 of differentiation the amount of DAn increased up to 25-35% of which 35% were expressing Girk2, a midbrain DA neuronal marker that was not expressed at day 35 and 45-60% of the DA neurons express FOXA2, another important transcription factor that confirm the midbrain fate. Even more importantly,...
La degenerazione dei neuroni dopaminergici (DA) del mesencefalo ventrale è considerata uno dei segni...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departament...
Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic mo...
Dopaminergic neurons (DAn) were efficiently differentiated from 6 different iPSC lines derived from ...
A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed t...
Parkinson’s disease (PD) is an incurable neurodegenerative disorder, mainly characterized by a progr...
Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecn...
A major obstacle on the way to understand the molecular pathogenesis of Parkinson’s disease (PD) and...
Parkinson’s disease (PD) is the second most common neurodegenerative disease and characterised by a ...
La maladie de Parkinson (MP) est une pathologie neurodégénérative caractérisée par la perte progress...
Parkinson’s disease (PD) is an incurable, chronically progressive neurodegenerative disease leading ...
Parkinson’s disease (PD) is a common neurodegenerative disorder diagnosed based on the presence of ...
Organoids are becoming particularly popular in modeling diseases that are difficult to reproduce in ...
Parkinson’s disease (PD) is the most frequently occurring movement disorder, with an increasing inci...
Parkinson’s disease (PD) is characterized by progressive neurodegeneration that primarily depletes d...
La degenerazione dei neuroni dopaminergici (DA) del mesencefalo ventrale è considerata uno dei segni...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departament...
Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic mo...
Dopaminergic neurons (DAn) were efficiently differentiated from 6 different iPSC lines derived from ...
A deeper understanding of early disease mechanisms occurring in Parkinson’s disease (PD) is needed t...
Parkinson’s disease (PD) is an incurable neurodegenerative disorder, mainly characterized by a progr...
Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecn...
A major obstacle on the way to understand the molecular pathogenesis of Parkinson’s disease (PD) and...
Parkinson’s disease (PD) is the second most common neurodegenerative disease and characterised by a ...
La maladie de Parkinson (MP) est une pathologie neurodégénérative caractérisée par la perte progress...
Parkinson’s disease (PD) is an incurable, chronically progressive neurodegenerative disease leading ...
Parkinson’s disease (PD) is a common neurodegenerative disorder diagnosed based on the presence of ...
Organoids are becoming particularly popular in modeling diseases that are difficult to reproduce in ...
Parkinson’s disease (PD) is the most frequently occurring movement disorder, with an increasing inci...
Parkinson’s disease (PD) is characterized by progressive neurodegeneration that primarily depletes d...
La degenerazione dei neuroni dopaminergici (DA) del mesencefalo ventrale è considerata uno dei segni...
Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departament...
Parkinson's disease (PD) is an incurable age-linked neurodegenerative disease with characteristic mo...