Add to ORKGThis study aimed to determine the relative importance of different functional and morphological pancreatic changes induced by the chronic administration of a sucrose-rich diet (SRD) to maintain normal glucose homeostasis. Male Wistar rats were fed either sucrose (SRD) or starch (CD) for 6 and 12 months. At both periods, serum glucose and triacylglycerol levels were significantly higher (P<0.05; paired and unpaired Student's t-test) in SRD rats. Serum insulin levels were significantly lower in SRD only at 12 months. At 6 months, the insulin secretion dose-response curve in SRD rats showed a shift to the left that was no longer observed at 12 months, when SRD islets decreased their response to 16 mM glucose. At 6 months, SRD rats showed a sig...
It is well known that glucocorticoids induce peripheral insulin resistance in rodents and humans. He...
Aims/hypothesis: The Zucker fatty (ZF) rat subjected to 60% pancreatectomy (Px) develops moderate di...
Insulin-secreting pancreatic β-cells adapt to obesity-related insulin resistance via increases in in...
This study aimed to determine the relative importance of different functional and morphological panc...
The aim of the present study was to clarify the mechanisms by which a sucrose-rich diet (SRD) produc...
The aim of this work was to study the possible relationship between pancreatic duodenal homeobox-1 (...
The total mass of pancreatic islet cells is a critical factor in glucose metabolic control. The aim ...
Aim: This study was undertaken to determine the effect of 15aa-INGAP upon insulin secretion. Materia...
Background: Tyrosine hydroxylase (TH) activity and its possible participation in the control of insu...
β-Cell mass, hexokinase/glucokinase (HK/GK) activity, glucose metabolism and insulin secretion were ...
Objectives: To study the chronological appearance of pancreatic islet neogenesis–associated protein ...
Objective. Current models of islet neogenesis either cause substantial pancreatic damage or continuo...
AbstractThis study tests the hypothesis that islet peroxisome proliferator-activated receptor alpha ...
Pancreatic beta-cell function was studied in adult female rats, in which endogenous insulin demand w...
Functional studies of islets isolated from diabetic, nondiabetic and prediabetic BB rats were perfo...
It is well known that glucocorticoids induce peripheral insulin resistance in rodents and humans. He...
Aims/hypothesis: The Zucker fatty (ZF) rat subjected to 60% pancreatectomy (Px) develops moderate di...
Insulin-secreting pancreatic β-cells adapt to obesity-related insulin resistance via increases in in...
This study aimed to determine the relative importance of different functional and morphological panc...
The aim of the present study was to clarify the mechanisms by which a sucrose-rich diet (SRD) produc...
The aim of this work was to study the possible relationship between pancreatic duodenal homeobox-1 (...
The total mass of pancreatic islet cells is a critical factor in glucose metabolic control. The aim ...
Aim: This study was undertaken to determine the effect of 15aa-INGAP upon insulin secretion. Materia...
Background: Tyrosine hydroxylase (TH) activity and its possible participation in the control of insu...
β-Cell mass, hexokinase/glucokinase (HK/GK) activity, glucose metabolism and insulin secretion were ...
Objectives: To study the chronological appearance of pancreatic islet neogenesis–associated protein ...
Objective. Current models of islet neogenesis either cause substantial pancreatic damage or continuo...
AbstractThis study tests the hypothesis that islet peroxisome proliferator-activated receptor alpha ...
Pancreatic beta-cell function was studied in adult female rats, in which endogenous insulin demand w...
Functional studies of islets isolated from diabetic, nondiabetic and prediabetic BB rats were perfo...
It is well known that glucocorticoids induce peripheral insulin resistance in rodents and humans. He...
Aims/hypothesis: The Zucker fatty (ZF) rat subjected to 60% pancreatectomy (Px) develops moderate di...
Insulin-secreting pancreatic β-cells adapt to obesity-related insulin resistance via increases in in...