A high HLA expression in uveal melanoma (UM) is part of the prognostically unfavorable inflammatory phenotype. We wondered whether the presence of soluble HLA (sHLA) in the aqueous humour is associated with clinical, histopathological or genetic tumour characteristics, and represents tumour HLA expression and intratumoural inflammation. Aqueous humour from 108 UM patients was analysed for the presence of sHLA, using a Luminex assay specific for HLA Class I. Clinical and genetic parameters were compared between sHLA-positive and negative eyes. A qPCR analysis was performed on tumour tissue using a Fluidigm assay. In 19/108 UM-containing eyes, the sHLA level in the aqueous was above the detection limit. Tumours in sHLA-positive eyes were sign...
Purpose: Prognostic predictors in uveal melanoma (UM) consist of clinical, histomor-phologic, and ge...
Purpose. In uveal melanoma, different predictors of poor prognosis have been identified, including m...
PURPOSE. Antitumor T cells need expression of HLA class I molecules but can be inhibited by ligands ...
Purpose: To investigate whether we can identify different patterns of inflammation in the aqueous hu...
Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and inc...
Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and inc...
PURPOSE. The presence of an inflammatory phenotype, characterized by an increased expression of HLA ...
The treatment of uveal melanoma (UM) metastases or adjuvant treatment may imply immunological approa...
Hypoxia-inducible factor 1-alpha (HIF1a) and its regulator von Hippel–Lindau protein (VHL) play an i...
International audienceBackground: Tumor-derived soluble factors, including soluble HLA molecules, ca...
PURPOSE: The molecules of the HLA class I and II molecules as well as the MHC class I chain-related ...
Tumor biopsy can identify prognostic biomarkers for metastatic uveal melanoma (UM), however aqueous ...
As HLA Class I expression is an important target for cytotoxic T cells but an in inhibitor of NKcell...
AbstractHuman leukocyte antigen G (HLA-G) molecules corresponding to nonclassic class I genes of the...
Uveal melanoma is the most common primary intraocular malignancy. The metastatic spread is hematogen...
Purpose: Prognostic predictors in uveal melanoma (UM) consist of clinical, histomor-phologic, and ge...
Purpose. In uveal melanoma, different predictors of poor prognosis have been identified, including m...
PURPOSE. Antitumor T cells need expression of HLA class I molecules but can be inhibited by ligands ...
Purpose: To investigate whether we can identify different patterns of inflammation in the aqueous hu...
Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and inc...
Uveal melanoma (UM) with an inflammatory phenotype, characterized by infiltrating leukocytes and inc...
PURPOSE. The presence of an inflammatory phenotype, characterized by an increased expression of HLA ...
The treatment of uveal melanoma (UM) metastases or adjuvant treatment may imply immunological approa...
Hypoxia-inducible factor 1-alpha (HIF1a) and its regulator von Hippel–Lindau protein (VHL) play an i...
International audienceBackground: Tumor-derived soluble factors, including soluble HLA molecules, ca...
PURPOSE: The molecules of the HLA class I and II molecules as well as the MHC class I chain-related ...
Tumor biopsy can identify prognostic biomarkers for metastatic uveal melanoma (UM), however aqueous ...
As HLA Class I expression is an important target for cytotoxic T cells but an in inhibitor of NKcell...
AbstractHuman leukocyte antigen G (HLA-G) molecules corresponding to nonclassic class I genes of the...
Uveal melanoma is the most common primary intraocular malignancy. The metastatic spread is hematogen...
Purpose: Prognostic predictors in uveal melanoma (UM) consist of clinical, histomor-phologic, and ge...
Purpose. In uveal melanoma, different predictors of poor prognosis have been identified, including m...
PURPOSE. Antitumor T cells need expression of HLA class I molecules but can be inhibited by ligands ...