Associations of obesity and circulating insulin and glucose with breast cancer risk : a Mendelian randomization analysis
- Shu, X
- Wu, L
- Khankari, NK
- Shu, X-O
- Wang, TJ
- Michailidou, K
- Bolla, MK
- Wang, Q
- Dennis, J
- Milne, RL
- Schmidt, MK
- Pharoah, PDP
- Andrulis, IL
- Hunter, DJ
- Simard, J
- Easton, DF
- Zheng, W
- Alicia, B-FJ
- Anton-Culver, H
- Antonenkova, NN
- Arndt, V
- Aronson, KJ
- Auer, PL
- Barrdahl, M
- Baynes, C
- Beane Freeman, LE
- Beckmann, MW
- Behrens, S
- Benitez, J
- Bermisheva, M
- Blomqvist, C
- Bogdanova, NV
- Bojesen, SE
- Brauch, H
- Brenner, H
- Brinton, L
- Broberg, P
- Brucker, SY
- Brüning, T
- Burwinkel, B
- Cai, Q
- Caldés, T
- Canzian, F
- Carter, BD
- Castelao, JE
- Chang-Claude, J
- Chenevix-Trench, G
- David Cheng, T-Y
- Clarke, CL
- Conroy, DM
- Couch, FJ
- Cox, DG
- Cox, A
- Cross, SS
- Cunningham, JM
- Czene, K
- Daly, MB
- Doheny, KF
- Dörk, T
- dos-Santos-Silva, I
- Dumont, M
- Dunning, AM
- Dwek, M
- Earp, HS
- Eccles, DM
- Heather Eliassen, A
- Engel, C
- Eriksson, M
- Gareth Evans, D
- Fachal, L
- Fasching, PA
- Figueroa, J
- Fletcher, O
- Flyger, H
- Fritschi, L
- Gabrielson, M
- Gago-Dominguez, M
- Gapstur, SM
- García-Closas, M
- Gaudet, MM
- Ghoussaini, M
- Giles, GG
- Goldberg, MS
- Goldgar, DE
- González-Neira, A
- Guénel, P
- Hahnen, E
- Haiman, CA
- Håkansson, N
- Hall, P
- Hallberg, E
- Hamann, U
- Harrington, P
- He, W
- Hein, A
- Hicks, B
- Hillemanns, P
- Hogervorst, FB
- Hollestelle, A
- Hoover, RN
- Hopper, JL
- Howell, A
- Huang, G
- Jakubowska, A
- Janni, W
- John, EM
- Johnson, N
- Jones, K
- Jung, A
- Kaaks, R
- Kabisch, M
- Kerin, MJ
- Khusnutdinova, E
- Kitahara, CM
- Kosma, V-M
- Koutros, S
- Kraft, P
- Kristensen, VN
- Lambrechts, D
- Le Marchand, L
- Lindström, S
- Linet, MS
- Lissowska, J
- Loibl, S
- Lubinski, J
- Luccarini, C
- Lux, MP
- Maishman, T
- Kostovska, IM
- Mannermaa, A
- Manoukian, S
- Manson, JE
- Margolin, S
- Mavroudis, D
- Meijers-Heijboer, H
- Meindl, A
- Menon, U
- Meyer, J
- Mulligan, AM
- Neuhausen, SL
- Nevanlinna, H
- Neven, P
- Newman, WT
- Nielsen, SF
- Nordestgaard, BG
- Olopade, OI
- Olshan, AF
- Olson, JE
- Olsson, H
- Olswold, C
- Orr, N
- Perou, CM
- Peto, J
- Plaseska-Karanfilska, D
- Prentice, R
- Presneau, N
- Pylkäs, K
- Rack, B
- Radice, P
- Rahman, N
- Rennert, G
- Rennert, HS
- Romero, A
- Romm, J
- Saloustros, E
- Sandler, DP
- Sawyer, EJ
- Schmutzler, RK
- Schneeweiss, A
- Scott, RJ
- Scott, C
- Seal, S
- Seynaeve, C
- Smeets, A
- Southey, MC
- Spinelli, JJ
- Stone, J
- Surowy, H
- Swerdlow, AJ
- Tamimi, R
- Tapper, W
- Taylor, JA
- Terry, MB
- Tessier, DC
- Thöne, K
- Tollenaar, RAEM
- Torres, D
- Troester, MA
- Truong, T
- Untch, M
- Vachon, C
- Van Den Berg, D
- van den Ouweland, AMW
- van Veen, EM
- Vincent, D
- Waisfisz, Q
- Weinberg, CR
- Wendt, C
- Whittemore, AS
- Wildiers, H
- Winqvist, R
- Wolk, A
- Xia, L
- Yang, XR
- Ziogas, A
- Ziv, E
DOIAbstract
Background In addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear. Methods We conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We ...
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