The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture that is present in approximately 10 % of all enzymes. It is generally assumed that this ubiquity in modern proteomes reflects an essential historical role in early protein-mediated metabolism. Here, we provide quantitative and comparative analyses to support several hypotheses about the early importance of the TIM barrel architecture. An information theoretical analysis of protein structures supports the hypothesis that the TIM barrel architecture could arise more easily by duplication and recombination compared to other mixed α/β structures. We show that TIM barrel enzymes corresponding to the most taxonomically broad superfamilies also have t...
The (βα)<sub>8</sub>-barrel is among the most ancient, frequent, and versatile enzyme structures. It...
After the surprisingly low number of genes identified in the human genome, alternative splicing emer...
AbstractThe high representation of the TIM barrel as a scaffold for enzymatic proteins makes it an i...
The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture th...
AbstractRecent studies on triosephosphate isomerase (TIM)-barrel enzymes highlight the remarkable ve...
The conservation of the intrinsic dynamics of proteins emerges as we attempt to understand the relat...
Abstract The triosephosphate isomerase (TIM) barrel superfamily is a broad family of proteins, most ...
Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently s...
lationship), superfamilies (probable common evolution-ary origin) and folds (Murzin et al., 1995). P...
<div><p>Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has re...
The amino acid sequences of proteins have evolved over billions of years, preserving their structure...
Sequence divergence of orthologous proteins enables adaptation to a plethora of environmental stress...
How the amino acid sequence of a protein specify its three dimensional structure is referred as prot...
The (beta alpha)(8)-barrel is the most frequent and most versatile fold among enzymes [Höcker et al....
<div><p>After the surprisingly low number of genes identified in the human genome, alternative splic...
The (βα)<sub>8</sub>-barrel is among the most ancient, frequent, and versatile enzyme structures. It...
After the surprisingly low number of genes identified in the human genome, alternative splicing emer...
AbstractThe high representation of the TIM barrel as a scaffold for enzymatic proteins makes it an i...
The triosephosphate isomerase (TIM) barrel protein fold is a structurally repetitive architecture th...
AbstractRecent studies on triosephosphate isomerase (TIM)-barrel enzymes highlight the remarkable ve...
The conservation of the intrinsic dynamics of proteins emerges as we attempt to understand the relat...
Abstract The triosephosphate isomerase (TIM) barrel superfamily is a broad family of proteins, most ...
Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently s...
lationship), superfamilies (probable common evolution-ary origin) and folds (Murzin et al., 1995). P...
<div><p>Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has re...
The amino acid sequences of proteins have evolved over billions of years, preserving their structure...
Sequence divergence of orthologous proteins enables adaptation to a plethora of environmental stress...
How the amino acid sequence of a protein specify its three dimensional structure is referred as prot...
The (beta alpha)(8)-barrel is the most frequent and most versatile fold among enzymes [Höcker et al....
<div><p>After the surprisingly low number of genes identified in the human genome, alternative splic...
The (βα)<sub>8</sub>-barrel is among the most ancient, frequent, and versatile enzyme structures. It...
After the surprisingly low number of genes identified in the human genome, alternative splicing emer...
AbstractThe high representation of the TIM barrel as a scaffold for enzymatic proteins makes it an i...