A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute. A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsions while maintaining high yields and high oxygen exchange activity.Sponsorship: Illinois Institute of TechnologySponsorship: Northfield Laboratories, Inc.United States Paten
With the objective of developing a recombinant oxygen carrier suitable for therapeutic applications,...
Molecular biology offers the opportunity to construct hemoglobin molecules as blood substitutes tail...
A recombinant 130 kDa dihemoglobin which is made up of a single-chain tetra-α globin and four β glob...
A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin con...
peer reviewedThe problems posed by transfusion of homologous blood have led to the development of su...
Blood transfusion is still a critical therapy in many diseases, traumatic events and war battlefield...
Donor blood is a limited resource and its transfusion is associated with significant adverse effects...
Oxygen supply is a critical point in technical processes when aerobic cells are used in immobilized ...
Anoxia-reoxygenation leads to severe metabolic alterations, which result in a generalized inflammato...
Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been used as blood substitutes in surgery medic...
Hemoglobin (Hb) plays its vital role through structural and functional properties evolutionarily opt...
Cellulose can be easily oxidized to oxycellulose with periodic acid, which can serve as a carrier fo...
The investigation object is the oxygen carrier on base of the chemically-derivative hemoglobin. The ...
OBJECTIVE: To review the current data on perfluorocarbon (PFC) emulsions and haemoglobin (Hb) soluti...
A method of preparing methoxypoly (ethylene glycol)-poly-DL-lactide (PELA) microcapsule containing b...
With the objective of developing a recombinant oxygen carrier suitable for therapeutic applications,...
Molecular biology offers the opportunity to construct hemoglobin molecules as blood substitutes tail...
A recombinant 130 kDa dihemoglobin which is made up of a single-chain tetra-α globin and four β glob...
A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin con...
peer reviewedThe problems posed by transfusion of homologous blood have led to the development of su...
Blood transfusion is still a critical therapy in many diseases, traumatic events and war battlefield...
Donor blood is a limited resource and its transfusion is associated with significant adverse effects...
Oxygen supply is a critical point in technical processes when aerobic cells are used in immobilized ...
Anoxia-reoxygenation leads to severe metabolic alterations, which result in a generalized inflammato...
Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been used as blood substitutes in surgery medic...
Hemoglobin (Hb) plays its vital role through structural and functional properties evolutionarily opt...
Cellulose can be easily oxidized to oxycellulose with periodic acid, which can serve as a carrier fo...
The investigation object is the oxygen carrier on base of the chemically-derivative hemoglobin. The ...
OBJECTIVE: To review the current data on perfluorocarbon (PFC) emulsions and haemoglobin (Hb) soluti...
A method of preparing methoxypoly (ethylene glycol)-poly-DL-lactide (PELA) microcapsule containing b...
With the objective of developing a recombinant oxygen carrier suitable for therapeutic applications,...
Molecular biology offers the opportunity to construct hemoglobin molecules as blood substitutes tail...
A recombinant 130 kDa dihemoglobin which is made up of a single-chain tetra-α globin and four β glob...