Breast cancer is the most common cancer and the leading cause of cancer related deaths amongst women in the United States. In 15-20% of patients with breast cancer, patients do not express steroid receptors(ER/PR) and do not have amplification of HER2. This condition is called triple negative breast cancer (TNBC). Patients with TNBC have poor prognosis. No molecular targeted therapies are available to treat TNBC. Anthracyclines and taxane based therapies are effective with limited success, and are often toxic. As TNBC cells overexpress Epidermal Growth Factor Receptor (EGFR), it provides an attractive molecular tool for the targeted therapy. Deguelin, a rotenoid isolated from an African plant, Mundulea sericea has been shown to inhibit grow...
Several natural compounds, especially plant products and dietary constituents, are able to exhibit ‘...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annua...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5 % of all cancers diagnosed annu...
Treatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have ...
(Leguminossae) has shown both antiproliferative actions in various cancers including breast as well...
Head and neck squamous cell carcinoma (HNSCC) is known to be intrinsically resistant to inhibitors f...
<p>Deguelin affects EGFR/c-Met and their downstream target molecules such as p-STAT3, p-ERK, p-AKT, ...
Deguelin, a natural component derived from leguminous plants, has been used as pesticide in some reg...
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor ...
Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis indu...
Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Y...
Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung m...
Background. Deguelin has both antiproliferation and antimetastasis activities. However, high-dose de...
Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are highly aggre...
The aim of the study was to investigate the anticancer effects and the molecular mechanisms of degue...
Several natural compounds, especially plant products and dietary constituents, are able to exhibit ‘...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annua...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5 % of all cancers diagnosed annu...
Treatment of breast cancer patients with antiestrogens and aromatase inhibitor(s) or Herceptin have ...
(Leguminossae) has shown both antiproliferative actions in various cancers including breast as well...
Head and neck squamous cell carcinoma (HNSCC) is known to be intrinsically resistant to inhibitors f...
<p>Deguelin affects EGFR/c-Met and their downstream target molecules such as p-STAT3, p-ERK, p-AKT, ...
Deguelin, a natural component derived from leguminous plants, has been used as pesticide in some reg...
Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to have an anti-tumor ...
Objective: To investigate the effects of deguelin on the proliferation inhibition and apoptosis indu...
Liubo Chen,1,2,* Kai Jiang,1,2,* Haiyan Chen,1,3,* Yang Tang,1,2 Xinyi Zhou,1,2 Yinuo Tan,1,4 Ying Y...
Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung m...
Background. Deguelin has both antiproliferation and antimetastasis activities. However, high-dose de...
Among the different types of breast cancers, triple-negative breast cancers (TNBCs) are highly aggre...
The aim of the study was to investigate the anticancer effects and the molecular mechanisms of degue...
Several natural compounds, especially plant products and dietary constituents, are able to exhibit ‘...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annua...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5 % of all cancers diagnosed annu...