EFEK ANTIINFLAMASI EKSTRAK ETANOLIK HERBA ALFALFA (Medicago sativa L.) PADA TIKUS JANTAN YANG DIINDUKSI KARAGENIN BESERTA IDENTIFIKASI KANDUNGAN SENYAWA AKTIFNYA

ABSTRACTAlfalfa plant (Medicago sativa L.) contains of flavonoids compound, it has already known. One of the effects of flavonoids is anti-inflammatory effect of alfalfa herb (M. sativa L.). The purpose of this research to know about anti-inflammatory effect of alfalfa herb ethanolic extract on carragenan induced male rats and also to know the content of its active compound. Thirty male wistar rats were randomly divided into 5 group of 6. Group I, negative control, were treathed CMC-Na 0,5 %, group II, positive control, were treathed natrium diclofenac 6,3 mg/ kg BB. Group III, IV and V were treathed ethanolic extract of alfalfa herb orally dose 45 mg/ kg BW, 90 mg/ kg BW and 180 mg/ kg BW. Anti-inflammatory effect were measured of edema feet were done every 30 minutes for 6 hours using plestismometer. After edema feet data vs time got, then we can get AUC0-360 value and percentase anti-inflammatory effect. Statistic analytical used one way ANOVA (p