Dynamic DNA Methylation as an Essential Epigenetic Regulator of Memory Consolidation

This paper explores the current state of the field (2017) of the role that epigenetics plays in memory formation and consolidation. The paper focuses on DNA methylation, which generally silences transcription. In the brain, specifically in the hippocampus, genes thought to promote or suppress memory undergo dynamic and transient methylation pattern changes during memory formation. During memory consolidation, DNA methylation in the cortex may represent a means maintaining the neural connections that make up memory traces