A cholera model in a patchy environment with water and human movement

A mathematical model for cholera is formulated that incorporates direct and indirect transmission, patch structure, and both water and human movement. The basic reproduction number 72.0 is defined and shown to give a sharp threshold that determines whether or not the disease dies out. Kirchhoff\u27s Matrix Tree Theorem from graph theory is used to investigate the dependence of R-0 on the connectivity and movement of water, and to prove the global stability of the endemic equilibrium when R-0 \u3e 1. The type/target reproduction numbers are derived to measure the control strategies that are required to eradicate cholera from all patches. (C) 2013 Elsevier Inc. All rights reserved