Etabolism in compensatory growth . III. The urea, glucose and C02 entry rates in animal undergoing compensatory growth

Glucose (GER), Urea (UER) and C02 (C02 ER) entry rates were studied at four points in the growth curve viz: before feed restriction (PI) after 8 weeks of feed restriction (P2), after 3 weeks (P3) and 15 weeks (P4) following resumption ofad libitum feeding. Sixteen Merino wethers were used and offerred pelleted lucerne (Medicago sativa) ad libitum for 3 weeks; then they were divided into 2 groups of eight. Group I continued to be fed ad libitum and Group 11 was fed pelleted lucerne at half maintenance level for 8 weeks and then fed ad libitum until the end of experiment. During feed restriction (P2), UER, urinary urea and urea transferred from the blood to the gut were 74% lower in group II than those in group I due to the reduction of N intake . At P2 GER and C02ER were also lower (53% and 56%, respectively) because of the reduction of available glucose precursor and metabolic rate. Similarly AV concentration difference of glucose, glucose taken up by the hind-limb muscle and the percentage of glucose taken up by muscle that was oxidised were reduced by 52%, 86% and 48%, respectively . When animals resumed ad libitum feeding, the components of urea entry rate (except plasma urea concentration), GER and C02ER were markedly increased indicating A switch to the anabolic mode, followed by increased glucose taken up and oxidised by the hind-limb muscle . The significance of glucose in muscle metabolism during compensatory growth was shown in the dramatic increase in the actual rate of glucose oxidation per unit muscle weight . It appears that the priority of usage of glucose taken up by muscle during compensatory growth is for oxidation to both C02 and lactate. Key words: Glucose entry rate, C02 entry rate, plasma ure