Formulation and evaluation of controlled release matrix tablets of antihypertensive drug using natural and synthetic hydrophilic polymers

The present study is to prepare and evaluate controlled release matrix tablets of Losartan potassium using natural and synthetic polymers. Tablets were prepared by direct compression method using different drug: polymer concentration. Fourier Transform Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) study revealed no chemical interaction between drug and polymers used. Precompression and postcompression parameters complied with pharmacopoeial limit for the tablets. In-vitro release studies was performed and the results indicates that matrix tablet (F9) containing 50% w/w blend of natural and synthetic polymer has better controlled release for a period of 24 h