Phytochemical screening and evaluation of cytotoxic activity of Pandanus fascicularis L. (Fruits)

The present study was conducted to evaluate possible phytochemicals present, and cytoctoxic activity of extract of fruits of Pandanus fascicularis L. Phytochemical screening was carried out using the standard test methods of different chemical group. Evaluation of cytotoxic activity was done using the brine shrimp lethality bioassay. The aqueous, methanolic, ethanolic, ethyl acetate, pet ether and chloroform extracts show presence of maximum phytochemicals such as alkaloids, tannins, flavonoids, steroids, saponins, proteins, terpens, phenols, glycosides, carbohydrate in different fractions etc. During cytotoxicity test, the positive control groups showed nonlinear mortality rates at lower concentrations and linear rates at higher concentrations. The LC50 values of Chloroform extract was found 1.0636 µg/ml where the positive control vincristine sulphate showed LC50 at a concentration of 0.200µg/ml. Therefore, the plant extract possess potent cytotoxic effect