Use of the gaia guidewires in a contemporary multicenter registry of chronic total occlusion percutaneous coronary intervention

Background: We sought to examine the use of thecomposite core hydrophilic Gaia guidewires inchronic total occlusion (CTO) percutaneous coronaryintervention (PCI). Methods: Baseline clinical and angiographic characteristics and procedural outcomes of 847 CTO PCIs performed between 2015 and 2016 at 9 US centers in 825 patients were evaluated. Results: The mean patient age was 65.1±10 years and 87% were men. The Gaiaguidewires were increasingly being used (30.5% antegrade and 7.6% retrograde crossing attempts in2015 vs 47.9% antegrade and 20.5% retrograde crossing attempts in 2016; p\u3c0.0001 for both respectively). In antegrade crossing the Gaia wires were used in more complex lesions with higher Japanese chronic total occlusion scores (2.76±1.18 vs. 2.25±1.32, p\u3c.0001) and were associated with lower technical and procedural success rates (79.1% vs. 87.0%, p=0.006; 77.6% vs. 85.8%, p= 0.007) but similar incidence of major adverse events (MACE: 3.56% vs. 2.64%, p=0.501). In retrograde crossing useof the Gaia wires was associated with similar technical and procedural success rates (80.5% vs. 77.3%, p=0.645; 68.3% vs. 72.9%, p=0.0536), but higher incidence of MACE (17.07% vs. 5.48%, p=0.006). Conclusion: In a contemporary, multicenterregistry Gaia guidewires are commonly and increasingly being used, especially in more complex cases and are associated with high technical and procedural success rates. (Table presented)