Formulation and Evaluation of Aceclofenac and Famotidine Tablets for Floating Drug Delivery System

The Bilayered floating tablets containing famotidine SR and aceclofenac IR were successfully prepared by wet granulation method. • The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index and drug content. • The prepared granules also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability and drug content. The optimized formulation contains the average thickness of 5.4±0.042, average hardness of 6.4±0.14, average weight of 600±0.56, friability of 0.021 and 99.72% of drug content. • In the 8 trials, the optimized formulation was F4 trial which releases the famotidine in sustained manner similar to the release given by marketed famotidine SR sample i.e., in 1st hour it releases 19 % but the remaining drug release was sustained up to 12 hours and the same formulation which releases the aceclofenac immediately with in an hour since the tablet disintegrated with in 15 minutes. • The optimized tablets of formulation F4 were selected for stability studies and they were kept in two different temperatures. The stability studies confirmed that there was no significant difference over a stability testing period. “Hence it may be summarized that the formulation F4 prepared by wet granulation method might be a perfect and effective formulation for the treatment