Formulations and Evaluation of Oral Dispersible Tablets of Lafutidine by Direct Compression Method

The purpose of the study was to formulate and evaluvate oral dispersible tablets of Lafutidine. The results of the fourier. Transmission Infra–red spectroscopy confirm that both drug and excipients are compatible with each other and are devoid of intraction. The DSC thermogram of formulation the sharp endothermic peak of pure drug appeared at 99.690C which reveals that there was no interaction between drug and physical mixture. The results of pre compression studies like angle of repose, bulk density, tappe density,compressibility index and hausnerss ratio reveals that the prepared powder blends of all formulations were possess good floe properties. F1, F2, F3 formulations are prepared by using sodium carboxy methyl cellulose in 2%, 3%, 4% respectively. F4, F5, F6 formulations prepared by using cros povidne super disintegrants in 2%, 3%, 4% respectively. F7, F8, F9 formulation prepared by using pre gelatinized starch super disintegrants in 2%,3%,4% respectively. F10, F11, F12 formulation prepared by using combination of sodium carboxy methyl cellulose, cros povidone, pregelatinized starch in 3%, 4.5%,12% respectively. The prepared tablets were subjected to post compression evaluvations and the results indicate that the hardness, thickness and diameter of all the tablets are uniform, which ensure that all the tablets were of uniform size and shape with good resistants against mechanical damage. The tablets of all formulation contains uniform amount of drug, which ensures content uniformity of tablet formulations. The prepared tablets were within the limits of weight variation test, which in turn indicate uniform distribution of contents of the powder blends of each formulation. The friability of all the tablets was found to be