Anti Microbial activity of Ilavu Ver Chooranam (Bombax ceiba) and Anti Ulcer activity of Hingu chooranam

ILAVU VER CHOORANAM: The herb Ilavu Ver was collected from Varasa naadu, Theni (Dt) and purified then powered and stored. This drug was subjected to various studies by the author. Ilavu Ver Chooranam was selected for this study to evaluate the Anti – microbial activity, and to prove its efficacy and safety in Leucorrhoea. The trial drug has got more literature evidence for its efficacy in the Leucorrhoea. The Ilavu Ver chooranam was subjected to various process of investigations like pharmacognostic study phytochemical, chemical and physio-chemical analysis to report the creditability of drug. The pharmacological analysis showed that the drug has got significant Anti microbial activity. The clinical study showed improvement in the symptoms like excessive watery discharge, mucopurulent discharge, itching in vulva, lower abdominal pain, low back pain, dysuria etc. The results were found to be good in 82% of patients, moderate in 10% of patients and mild in 8% of patients. Bombax ceiba (Ilavu Ver chooranam) will be significantly safe and highly effective for Leucorrhoea (Vellai noi ). CONCLUSION: The Siddha drug “Ilavu ver chooranam” was tested for its efficacy in the management of vellai noi in this study. The model and study design demonstrates the feasibility of evaluating powdered form of Bombax ceiba (Ilavu Ver chooranam) in the management of Leucorrhoea (Vellai noi). The literature reviews along with phytochemical, chemical constituent’s aids in justification of drug.Standardisation of tested drug through various physico chemical analysis and pharmacognostic study for quality and acceptability of drug. The availability, collection and preparation of the drug is easy and also economical. Presence of of flavanoids, Triterpinoids, Steroids, Phenols, Tannin, Saponin. helps in treating leucorrhoea because of these promote anti – microbial activity. Tannin is powerful astringent. So acts on vaginal mucous membrane thus decreasing discharge and also occur anti-microbial activity. The trial drug was subjected to pharmacological, clinical studies were analysed and revealed that the trial drug has potent Anti microbial activity. The antibacterial and antifungal activity of Ilavu Ver Chooranam was tested. For the Ilavu Ver Chooranam, the maximum inhibition zone was observed for the fungal Candida 10mm at the concentration of 100μg/ml. The clinical study showed improvement in the symptoms like excessive watery discharge, mucopurulent discharge, itching in vulva, lower abdominal pain, low back pain, dysuria etc. The results were found to be good in 82% of patients, moderate in 12% of patients and mild in 6% of patients. . Statistical analysis shows p value < 0.05 which is considered very statistically significant. All the above studies have proved that the trial drug Ilavu. PART II: HINGU CHOORANAM: Herbo- mineral drug Hingu chooranam was prepared as per Sasthrik method and evaluate the Anti – ulcer activity, and to prove its efficacy and safety in peptic ulcer disease. Hingu chooranam is a herbo mineral drug which contains 8 drugs. In the siddha literature “ Gunapadam mooligai and thaadhu vaguppu” all drugs are indicated for Gunmam. The Hingu chooranam was subjected to various process of like phytochemical, chemical and physico-chemical analysis to report the creditability of drug. The physico chemical analysis expressed the presence of calcium, potassium, magnisum, zinc, Iron which is known well for its ulcer curing property. The pharmacological analysis showed that the drug has got significant Anti ulcer activity. The clinical study showed improvement in the symptoms like epigatric pain, heart burn, epigatsric tenderness, nausea and vomiting, abdominal discomfort, loss of appetite, constipation etc. The results were found to be good in 72% of patients, satisfactory in 10% of patients , moderate in 14% of patients and poor in 4% of patients. Statistical analysis shows p value < 0.05 which is considered very statistically significant. This present study suggests that Hingu Chooranam has the remarkable medicinal value against the disease Peptic ulcer without any adverse effect. CONCLUSION: The trial drug Hingu chooranam is selected from the classical siddha literature. Sarabendhirar vadhya muraigal- Gunmaroga sigichai by for the evaluation of safety and efficacy of Peptic Ulcer Disease. The trial drug was identified and authenticated by the gunapadam experts. The drug is easily available. Then preparation and preservation of the drug is easy and also economical. The literary reviews along with Phytochemical, chemical constituents, supports the efficient activity of the drug, Standardisation of the drug was done by physic chemical analysis. Hingu chooranam is a herbo mineral drug which contains 8 drugs. In the siddha literature “Gunapadam mooligai and thaadhu vaguppu” all drugs are indicated for Gunmam. Tannins are used in peptic ulcer disease because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins. In peptic ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Tannins present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and also involved in gastrointestinal tract anti-inflammatory processes. The presence of Triterpenes, Steroids, Anthraquinine, Saponin and Coumarin in Hingu chooranam is most effective for peptic ulcer disease. Because of these promote anti –ulcer activity. Zinc is extremely important in ulcers, irritable bowel syndrome, yeast infections, colitis, and many other digestive problems. The trial drug was subjected to pharmacological, clinical studies were analysed that the trial drug has potent Anti Ulcer activity. The clinical study showed improvement in the symptoms like epigatric pain, heart burn, epigatsric tenderness, nausea and vomiting, abdominal discomfort, loss of appetite, constipation etc. The results were found to be good in 72% of patients, satisfatory in 10% of patients, moderate in 14% of patients and poor in 4% of patients. Statistical analysis shows p value < 0.05 which is considered very statistically significant. No adverse effects were produced during the entire clinical study. From the above observation, I conclude that the Hingu chooranam is most effective for Peptic ulcer disease (Gunmam)