Evaluation of Safety and Efficacy of Collagen Peptide as an Add on Therapy to Standard Treatment in Comparison with the Standard Treatment alone in the Management of Patients with Knee Joint Osteoarthritis

AIM OF THE STUDY: To compare the efficacy and tolerability of collagen peptide as an Add on therapy to Standard treatment compared to standard treatment alone in the management of patients with knee joint osteoarthritis. METHODOLOGY: This was an open label, comparative, randomized, prospective study. This study included 60 patients with osteoarthritis, who were randomized into two groups of 30 each. Control group received standard therapy (T.Diclofenac 100mg/day, T.Ranitidine 150mg twice daily and physiotherapy) and Study group received collagen peptide (10g/day) in addition to standard therapy for a period of 12 weeks. They were followed-up once in 2weeks for 12weeks. Pain, stiffness and functional disability were assessed using visual analogue pain scale (VAS) and WOMAC index at baseline and at the end of the study. RESULTS: 126 patients were screened out of which 60 patients were included in the study and all patients completed the study and were included in Analysis. On comparing the groups at the end of 12 weeks there was a statistically significant reduction in VAS and WOMAC INDEX score in Study group. No significant difference in the incidence of adverse events noted between the two groups. CONCLUSION: Collagen peptide along with standard therapy is highly effective in reducing Pain, Stiffness and Functional disability in patients with Knee joint Osteoarthritis