A Study of Prognostic Significance of Microalbuminuria in Nondiabetic Patients with Recent Ishcemic Cerebrovascular Stroke

1. The study population consisted of 60 recent ischemic stroke patients of age 48.69+15.20 years with 41 males (68.33%) and 19 females (31.67%). 2. The patients without microalbuminuria included 29, age and sex matched individuals. 3. The patients with microalbuminuria and without microalbuminuria were matched for predisposing factors that included smoking and alcohol. 4. Among the patients with microalbuminuria, 15 (49.39%) had right hemiparesis, 16 (51.61%) had left hemi paresis. 5. CT scan results revealed that middle cerebral artery infarct predominated the study population (right and left each 43.75%). 6. The blood sugar levels were higher in with microalbuminuria (108.66+8.683) compared to without microalbuminuria (107.83+8.21) despite being in non-diabetic range but were not statistically significant. Other parameters like blood pressure, blood urea and serum creatinine were similar among the patients with microalbuminuria and without microalbuminuria. 7. In patients with recent ischemic stroke, 3 1 pts (51.65%) had microalbuminuria while 21 patients (49.35%) had no microalbuminuria. 8. 12/31 patients with microalbuminuria (38.70) had altered consciousness while 2/29 patients without microalbuminuria (6.89) had altered consciousness. Hence microalbuminuria was found to be associated with more severe stroke. 9. 8/31 patients with microalbuminuria (25.80) had ECG changes of ischemic heart disease while 1/29 (3.45%) patients without MA had IHD changes. Hence, microalbuminuria could be associated with not just stroke, but also other atherosclerotic vascular diseases. 10. The mean age of patients with microalbuminuria was 47.19+14.03 while that of patients without MA was 48.69+15.23 years. The difference was not statistically significant level. 11. In patients with microalbuminuria, total cholesterol was 204+13.78, and triglycerides 192.45+35.59 while in patients without microalbuminuria, total cholesterol was 193.9+23.52, and triglycerides 157.93+33.49. The difference was statistically significant. 12. The Scandinavian Stroke Scale was low in patients with microalbuminuria (7.89-13.85) when compared to patients without microalbuminuria (20.30-14). Hence significant correlation was found between microalbuminuria and the severity of the neurological deficit. 13. The Barthel index was low in patients with microalbuminuria (50-70) when compared to patients without MA (45-100). Hence, there was significant correlation between microalbuminuria and poor stroke outcome. CONCLUSION: Various clinical studies have documented microalbuminuria as a risk factor for ischemic stroke. The present study found microalbuminuria in 51.66% of non-diabetic recent ischemic stroke patients and is consistent with previous studies associating MA with atherosclerotic vascular disease. In the present study, we have shown that the measurement of microalbuminuria was found to be reliable predictor of stroke outcome 6 weeks after stroke