Comparison of Esmolol and Magnesium Sulphate for Attenuation of Haemodynamic Stress response to Laryngoscopy and Intubation in Elective ENT Surgeries

SUMMARY: This randomized prospective single blinded study was designed to evaluate efficacy of Esmolol and Magnesium sulphate in attenuating hemodynamic stress response to laryngoscopy and intubation .Ninety patients of ASA PS I and II were randomly allocated into three groups of thirty each. P---received normal saline, E—Esmolol 1.5mg/kg, M—Magnesium Sulphate 50mg/kg, The following observations were made: 1. Group E showed maximum attenuation of heart rate and blood pressure. 2. Group M also showed significant attenuation of blood pressure response but produced tachycardia on infusion of the drug. Heart rate response was not statistically significant compared to group E. 3. All patients recovered well. 4. Incidence of side effects was not significant between the groups. CONCLUSION: From this study, it is concluded that hemodynamic changes to laryngoscopy and intubation can be attenuated by giving intravenous Esmolol 1.5mg/kg. Esmolol is effective in blunting the response followed by Magnesium Sulphate which blunts the hypertensive response but produces tachycardia during infusion of the drug. Placebo was ineffective in blunting hemodynamic stress response to laryngoscopy and intubation