Formulation and Evaluation of Transdermal Patch of Aqueous Extract of Azadirachta Indica A Juss

INTRODUCTION:Traditional system of medicine is one of the centuries old practice and longserving companion to humankind in the fight against disease and in leading a healthy life. Indigenous people have been using the unique approach of their traditional system of medicine for centuries and among the most renowned are the Chinese, Indian, African systems of medicine. Traditional medicine refers to any ancient and culturally based healthcare practice differing from scientific medicine and is largely transmitted orally by communities of different cultures.[1] The World Health Organization (WHO) observes that it is difficult to assign one definition to the broad range of characteristics and elements of traditional medicine, but that a working definition is essential. It thus concludes that the traditional medicines ‘‘[include] diverse health practices, approaches, knowledge and beliefs incorporating plant, animal and mineral based medicines, spiritual therapies, manual techniques and exercises applied singularly or in combination to maintain wellbeing, as well as to treat, diagnose or prevent illness. AIM:The aim of Novel Drug Delivery System is to provide a therapeutic amount of drug to the appropriate site in the body to accomplish promptly and then maintain the desired drug concentration. The drug- delivery system should deliver drug at a rate control by the necessarily of the body over a specified term of treatment. 2. To prepare and evaluate Transdermal Patch of Aqueous extract of Azadirachta indica A. juss using different polymers OBJECTIVE: 1. To convert the herbal extract into a novel dosage form 2. To provide a direct entry of aqueous extract into the systemic circulation to give sustained action 3. To develop a novel topical formulation of aqueous extract of neem leaves for the effective treatment of Skin infections SUMMARY: The various formulation parameters, Drug-Polymer ratios and permeation enhancers were optimized to get thin, transparent, smooth, stable and high permeable transdermal patches. The FTIR graphs of drug, excipients and formulations showed that there is no extra peak (or) broadening of peaks were observed and thus it indicates that there is no incompatibility between drug and excipients. From the optimization, best 2 formulations P2 & S5 were selected based on physico chemical evaluation and in vitro drug diffusion study 0.3ml of glycerin was added as plasticizer to produce a flexible patch without having major influence on their diffusion property. If the amount exceeds, the film loses its flexibility and become stiff. The plasticizer diffuses through the patch and softens the polymer particles. This softening promotes latex coalescence and patch formation. All the six batches were evaluated for Percentage Moisture uptake, Percentage Moisture content, Thickness, Folding Endurance, Percentage Drug content, Percent Elongation, Tensile strength and Adhesive strength. The formulations P2 & S5 showed maximum % Moisture uptake, Moisture content, Thickness, folding endurance, % Drug content, Percent elongation, Tensile strength No significant difference in drug content was observed between the patches among the six formulations. This indicates the homogenous dispensing of drug during the patch preparation. CONCLUSION: The ex vivo studies results showed 61.01% of drug diffusion at the end of 8 h. It concluded the controlled diffusion property of through the skin . The stability studies results showed that there is no significant change from its initial nature till the period of three months at 40˚C ±2˚C/75 5% RH. The present work has achieved the objectives of formulation of transdermal patch of Aqueous extract of Azadirachta indica by using different polymers. The diffusion kinetics confirms that the formulation followed zero order, non-fickian diffusion model