A Study of Haematological Profile and Serum Iron Indices in Non Dialysis Chronic Kidney Disease Patients

AIM : To assess the Haematological profile and Serum Iron indices in non-dialysis Chronic Kidney Disease patients BACKGROUND AND OBJECTIVES: Anemia is a common and early complication of chronic kidney disease patients. One contributing factor is iron deficiency, which may be particularly problematic during erythropoietin therapy. MATERIALS AND METHODS: It is a cross-sectional study conducted in Department of Medicine and Nephrology, Govt Rajaji Hospital, Madurai. A total of 54 patients were included in our study who satisfied the diagnostic criteria of CKD and patients underwent clinical and renal parameters, haematological profile and iron status. For comparison of the results with the general population adequate number of controls were taken. RESULTS: Our study results showed low level of Haemoglobin, and packed cell volume with increase in severity of chronic kidney disease. Bleeding time was increased in 5.6% patients and elevated ESR was present in more than half of patients. Anemia was universal in our population. Normocytic normochromic anemia was found in 70.4 % of the patients and microcytic hypochromic anemia in another 20.4%, and 9.2% had both type of peripheral smear picture. Applying the NKF-K/DOQI guidelines for nondialysis chronic kidney disease to our population it was found that nearly 38.9% of the study population did not have target serum ferritin of 100 ng/ml and 44.4% of study population did not have target TSAT of >20%. CONCLUSION: So it is vital to address this issue of iron deficiency in patients with chronic kidney disease so that necessary investigations can be undertaken to find the cause of iron deficiency if any. So every effort should be done to identify the cause of anemia in CKD patients and treat the coexistent iron deficiency anemia in chronic kidney disease patients. And other haematological parameters should be monitored to find out coexisting abnormality