A Study on Role of HBsAg Quantification in patients with Chronic Hepatitis B Infection and Predicting its Response to Treatment

AIM : To study the correlation of HBsAg quantification levels with HBV DNA in patients with chronic hepatitis B infection.Also to study the role of qHbsAg levels in predicting the response to antiviral therapy in chronic hepatitis B infection. MATERIALS AND METHODS : one year prospective study conducted between January 2014-2015 at department of digestive health and diseases, kilpauk medical college,chennai. All patients of chronic hepatitis B infection were included in the study. Baseline liverfunction tests, HbsAg quantification and HBVDNA levels were done. In treatment group the above values are repeated every 12 weeks for 36 weeks. RESULTS : Total of 160 patients were included and among them 24 were in treatment group. The results are as follows. In the treatment naïve group, serum HBsAg levels are higher in HBeAg positive group than HBeAg negative group with a mean of 4.25logIU/ml and 2.81logIU/ml respectively . so qHBsAg levels had significant correlation with HBVDNA levels in HBeAg positive group ( P